In this randomized trial we investigated whether intra-uterine insemination (IUI) in couples with male subfertility leads to a higher probability of conception than timed intercourse after ovarian stimulation with human menopausal gonadotrophin (HMG) and human chorionic gonadotrophin (HCG). A total of 76 couples started 249 cycles, of which 47 were cancelled to prevent multiple pregnancies or hyperstimulation. After 202 completed treatment cycles, 15 pregnancies occurred, 11 after IUI and four after timed intercourse. The pregnancy rate per completed cycle with IUI was 10.3% (95% confidence interval: 5.5-17.5%) and 4.2% (1.2-10.1%) with timed intercourse. Compared with the estimated spontaneous chance to conceive, IUI after ovarian stimulation appeared to be more effective in the first three cycles. We conclude that in subfertile couples with a male factor, IUI tends to improve the probability of conception as compared to timed intercourse when ovarian stimulation is applied, and we advise such treatment for three cycles.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/oxfordjournals.humrep.a138386 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association of disability, walking, manual dexterity, and quality of life with sexual dysfunction in multiple sclerosis patients.
Acta Neurol Belg
December 2024
Department of Biostatistic, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, MD, Turkey.
Background/objective: This study aims to examine the relationship between sexual dysfunction and walking ability, manual dexterity, disability, and quality of life in patients with multiple sclerosis.
Methods: 51 sexually active MS patients (28 females and 23 males) participated in the study. Demographic data were recorded for all patients.
Similar accuracy and patient experience with different one-step ovulation predictor kits.
Fertil Steril
September 2024
Department of Obstetrics and Gynecology, Center for Infertility and Reproductive Surgery, Brigham and Women's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.
Objective: To examine the accuracy of five different at-home ovulation predictor kits (OPKs), and to understand patient experience with the use of those kits.
Design: Prospective cohort study.
Setting: Single academic fertility practice.
Ibuprofen delays ovulation by several hours: prospective controlled study in natural cycles with HCG-triggered ovulation.
Reprod Biomed Online
September 2024
Division of Gynecological Endocrinology and Reproductive Medicine, University Women's Hospital, Inselspital, Berne, Switzerland.
Research Question: Does ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), delay ovulation?
Design: Two-stage, proof-of-concept, controlled study, assessing the percentage of non-ovulated follicles 42 h after HCG injection in patients taking ibuprofen. The intervention group consisted of women undergoing natural cycle IVF treatment taking ibuprofen 3 × 400 mg per day. The control group consisted of women undergoing timed sexual intercourse or intrauterine insemination.
Impact of repeated ovarian hyperstimulation on the reproductive function.
J Reprod Immunol
August 2024
Graduate Program in Medical Sciences, Universidade de Fortaleza (UNIFOR), Fortaleza, CE 60.811-905, Brazil; Medical School, Universidade de Fortaleza (UNIFOR), Fortaleza, CE 60.811-905, Brazil; CONCEPTUS - Reproductive Medicine, Fortaleza, CE 60.170-240, Brazil. Electronic address:
One of six couples (17.5 % of the adult population) worldwide is affected by infertility during their lifetime. This number represents a substantial increase in the prevalence of this gynecological condition over the last decade.
View Article and Find Full Text PDFDifferences in medically assisted reproduction use by sexual identity and partnership: a prospective cohort of cisgender women.
Hum Reprod
June 2024
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Study Question: Does medically assisted reproduction (MAR) use among cisgender women differ among those with same-sex partners or lesbian/bisexual identities compared to peers with different-sex partners or heterosexual identities?
Summary Answer: Women with same-sex partners or lesbian/bisexual identities are more likely to utilize any MAR but are no more likely to use ART (i.e. IVF, reciprocal IVF, embryo transfer, unspecified ART, ICSI, and gamete or zygote intrafallopian transfer) compared to non-ART MAR (i.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!