A rapid, simple and accurate HPLC method is presented for the determination of nadoxolol in human plasma. Nadoxolol from plasma was successfully purified using an Adsorbex column. The samples were chromatographed on a LiChrosorb RP-18 (10 microns) column with methanol-acetonitrile-phosphate buffer (pH 3.3) (70:20:10) as the mobile phase. Detection was carried out at 254 nm. The method was tested for linearity (from 5 to 25 micrograms/ml), recovery (85%) and precision (C.V. = 4.5%).
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| http://dx.doi.org/10.1016/0378-4347(94)00291-6 | DOI Listing |
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