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Pumpkin Soluble Dietary Fiber instead of Insoluble One Ameliorates Hyperglycemia via the Gut Microbiota-Gut-Liver Axis in db/db Mice.
J Agric Food Chem
January 2025
College of Food Science and Engineering, Northwest A&F University, Yangling, 712100 Shaanxi, China.
Pumpkin extract has been shown to alleviate hyperglycemic symptoms by improving glucose metabolism disorders. However, the specific active components responsible for its hypoglycemic effects and the underlying molecular mechanisms remain unclear. In this study, db/db mice underwent a 4-week dietary intervention with two pumpkin flours (PF1 and PF2), total dietary fiber (TDF), soluble dietary fiber (SDF), and insoluble dietary fiber (IDF), with acarbose serving as a positive control.
View Article and Find Full Text PDFGreen hydrothermal synthesis of nickel and zinc-doped nickel ferrite nanoparticles using extracts and their biological studies.
Heliyon
January 2025
Institute of Fundamental and Applied Research, National Research University TIIAME, Kori Niyoziy 39, 100000 Tashkent, Uzbekistan.
Convectional drugs have failed to tackle the increasing public health challenge of Cancer and diabetes. Phytochemical conjugated nanoparticles are providing safer therapeutic alternatives to address this global challenge. Nanoparticles of nickel, iron and zinc are especially useful because of their magnetic properties, abilities to prevent the onset or slow the progression of these diseases.
View Article and Find Full Text PDFIsolation and Characterization of Lactic Acid Bacteria From "" Having the Ability to Produce α-Glucosidase Inhibitors.
Int J Microbiol
January 2025
Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Riau, Pekanbaru, Riau 28293, Indonesia.
Alpha-glucosidase inhibitors are one of the therapies used for treating type 2 diabetes by inhibiting the absorption of carbohydrates in the gastrointestinal tract. In addition to antimicrobial activity, some probiotic species show -glucosidase inhibitor activity, making them potential alternative therapies for type 2 diabetes. This study aimed to characterize probiotics from "," a traditional food from North Sumatra, Indonesia, that exhibit -glucosidase inhibition, potentially useful for type 2 diabetes treatment.
View Article and Find Full Text PDFα-Amylase inhibitory potential of dihydropyrano coumarins: In silico and DFT analysis.
3 Biotech
February 2025
Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, 632014 India.
Unlabelled: Coumarin derivatives are one of the naturally occurring bioactive molecule. Dihydropyrano coumarins are one of the medicinally important derivatives of coumarin which have been reported to exhibit various bioactivity. However, there are no reports on their antihyperglycemic activities.
View Article and Find Full Text PDFSubstituted piperazine conjugated to quinoline-thiosemicarbazide as potent α-glucosidase inhibitors to target hyperglycemia.
Sci Rep
January 2025
Natural and Medical Sciences Research Center, University of Nizwa, Birkat Al Mauz, P. O. Box 33, Nizwa, Oman.
Diabetes mellitus, particularly type 2 diabetes, is a growing global health challenge characterized by chronic hyperglycemia due to insulin resistance. One therapeutic approach to managing this condition is the inhibition of α-glucosidase, an enzyme involved in carbohydrate digestion, to reduce postprandial blood glucose levels. In this study, a series of thiosemicarbazide-linked quinoline-piperazine derivatives were synthesized and evaluated for their α-glucosidase inhibitory activity, to identify new agents for type 2 diabetes management.
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