We report a case of spasmodical laughter due to a strictly unilateral lesion located in the pons and the caudal part of the mesencephalon. Pathophysiology of this particular symptom is reviewed.
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J Neurosci
January 2011
Department of Communication Sciences and Disorders, James Madison University, Harrisonburg, Virginia 22807, USA.
Spasmodic dysphonia (SD) is a rare neurological disorder that emerges in middle age, is usually sporadic, and affects intrinsic laryngeal muscle control only during speech. Spasmodic bursts in particular laryngeal muscles disrupt voluntary control during vowel sounds in adductor SD and interfere with voice onset after voiceless consonants in abductor SD. Little is known about its origins; it is classified as a focal dystonia secondary to an unknown neurobiological mechanism that produces a chronic abnormality of laryngeal motor neuron regulation during speech.
View Article and Find Full Text PDFJ Clin Neurosci
June 2010
Department of Radiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India.
Rev Neurol (Paris)
January 2009
Service de neurologie, Hôtel-Dieu de France, Achrafieh, Beyrouth, Liban.
Introduction: Spasmodic laughter is a classical sign of pseudobulbar palsy, but it has never been reported, to our knowledge, to provoke syncope.
Case Report: A 63-year-old hypertensive and diabetic man with peripheral neuropathy and lacunar pseudobulbar palsy presented with three episodes of spasmodic laughter which had induced syncope. No new episode was observed after the beginning of low dose bisoprolol.
Rev Neurol (Paris)
March 2004
Department of Neurology, Saint Louis University School of Medicine, Missouri, USA.
Fou rire prodromique (prodrome of crazy laughter) is a rarely described nosological entity. In 1903, Charles Féré, a French neurologist, introduced the term fou rire prodromique to describe pathological laughter heralding an apoplectic event. He was also among the first to describe gelastic epilepsy.
View Article and Find Full Text PDFRev Neurol (Paris)
March 1995
Service de Neurologie, Centre Hospitalier, Saint-Germain-en-Laye.
We report a case of spasmodical laughter due to a strictly unilateral lesion located in the pons and the caudal part of the mesencephalon. Pathophysiology of this particular symptom is reviewed.
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