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Efficacy and safety of mirikizumab in patients with moderately-to-severely active Crohn's disease: a phase 3, multicentre, randomised, double-blind, placebo-controlled and active-controlled, treat-through study.
Lancet
December 2024
Dr Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Background: Mirikizumab, a humanised monoclonal antibody that inhibits IL-23p19, is effective in moderate-to-severe ulcerative colitis. We aimed to evaluate the efficacy and safety of mirikizumab in patients with moderately-to-severely active Crohn's disease.
Methods: VIVID-1 was a global phase 3, randomised, double-blind, double-dummy, placebo-controlled and active-controlled, treat-through study.
Evaluation of the toxicity of translaminar insecticides against the soybean tentiform leafminer (Lepidoptera: Gracillariidae), a potential new pest of soybean.
J Econ Entomol
December 2024
Department of Entomology, University of Minnesota, Saint Paul, MN, USA.
Macrosaccus morrisella (Fitch) (Lepidoptera: Gracillariidae) is a leaf-mining microlepidopteran native to North America recently reported feeding on soybean in the United States and Canada. Control methods for the management of this pest remain unknown. The insecticides Agri-Mek SC (abamectin) and Endigo ZXC (lambda-cyhalothrin + thiamethoxam) were evaluated for: (i) effects against immature stages of M.
View Article and Find Full Text PDFPotential insect threats to pennycress, Thlaspi arvense (Brassicales: Brassicaceae), an emerging oilseed cover crop.
J Insect Sci
July 2024
Department of Entomology, University of Minnesota, 1980 Folwell Avenue, Saint Paul, MN 55108, USA.
Pennycress (Thlaspi arvense L.) is an annual plant in temperate regions that often grows as a weed. Pennycress is being domesticated as a new winter cover crop and oilseed crop for incorporation in the Midwest United States corn-soybean rotation, where it could offer economic and environmental benefits.
View Article and Find Full Text PDFImmature development and adult longevity of the soybean tentiform leafminer (Lepidoptera: Gracillariidae).
Environ Entomol
August 2024
Department of Entomology, University of Minnesota, Saint Paul, MN, USA.
The leaf-mining microlepidopteran, Macrosaccus morrisella (Fitch) (Lepidoptera: Gracillariidae), has emerged as a new pest of soybean, Glycine max (L.) Merrill (Fabales: Fabaceae), in Canada and the United States, but little is known about its life history traits. Thus, this study was conducted to assess the immature developmental rate of M.
View Article and Find Full Text PDFTravel surveillance uncovers dengue virus dynamics and introductions in the Caribbean.
Nat Commun
April 2024
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
Dengue is the most prevalent mosquito-borne viral disease in humans, and cases are continuing to rise globally. In particular, islands in the Caribbean have experienced more frequent outbreaks, and all four dengue virus (DENV) serotypes have been reported in the region, leading to hyperendemicity and increased rates of severe disease. However, there is significant variability regarding virus surveillance and reporting between islands, making it difficult to obtain an accurate understanding of the epidemiological patterns in the Caribbean.
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