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Reconstructing the Social Construction of Reality.
Br J Sociol
January 2025
AAU Business School, Aalborg University, Aalborg, Denmark.
What is the relationship between legitimation and institutionalization? We take a fresh look at a more complex and nuanced landscape than has previously been documented. Our approach is to view legitimation and institutionalization as separate, though related, processes. We engage in theory building to develop a typology suggesting four different ways in which the social construction of reality can be achieved: instantiating (mutual causal emergence, coming into being), realizing (legitimating toward institutionalization), aspiring (legitimating from institutionalization) and missing (mutual causal suppression, unrealized potential).
View Article and Find Full Text PDFRational multienzyme architecture design with iMARS.
Cell
January 2025
State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China; Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China; Research Center for Proteins & Bits, Lumy Biotechnology, Changzhou, Jiangsu 213200, China. Electronic address:
Biocatalytic cascades with spatial proximity can orchestrate multistep pathways to form metabolic highways, which enhance the overall catalytic efficiency. However, the effect of spatial organization on catalytic activity is poorly understood, and multienzyme architectural engineering with predictable performance remains unrealized. Here, we developed a standardized framework, called iMARS, to rapidly design the optimal multienzyme architecture by integrating high-throughput activity tests and structural analysis.
View Article and Find Full Text PDFefficacy and safety of systemically administered serinol nucleic acid-modified antisense oligonucleotides in mouse kidney.
Mol Ther Nucleic Acids
March 2025
Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Nucleic acid medicine encompassing antisense oligonucleotides (ASOs) has garnered interest as a potential avenue for next-generation therapeutics. However, their therapeutic application has been constrained by challenges such as instability, off-target effects, delivery issues, and immunogenic responses. Furthermore, their practical utility in treating kidney diseases remains unrealized.
View Article and Find Full Text PDFPrecision Oncology: A Global Perspective on Implementation and Policy Development.
JCO Glob Oncol
January 2025
International Cancer Patient Coalition, Brussels, Belgium.
Despite the acknowledged merits of precision oncology (PO) and its increasing global implementation, its full potential for advancing care and prevention remains unrealized. The benefits are currently accessible to only limited patient segments because of multifaceted barriers. Successful implementation hinges on various factors-scientific complexities not limited to technical, clinical, regulatory, economic, administrative, and health care policy-related challenges.
View Article and Find Full Text PDFThe underappreciated roles of aboveground vertebrates on belowground communities.
Trends Ecol Evol
January 2025
Department of Bioscience and Biotechnology, Fukui Prefectural University, Fukui, Japan.
In recent decades, evidence of interactions between aboveground and belowground (i.e., soil) subsystems has accumulated.
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