A model of gingival inflammation was performed in Sprague-Dawley rats weighing 180-200 g. Mechanical bamboo stick-induced injury was inflammatory when bacteria contaminated the sticks. Bacteria were first obtained from gingival fluid collected from a patient with adult periodontitis. Another strain from Institut Pasteur (IP 6444) induced similar inflammation. Inflammation was then quantified 10 days later by means of elastase assays performed in gingival extracts. In parallel, elastic structures were observed and elastic fibers were quantified by automated image analysis. This technique of "impaction" was able to induce a gingival inflammatory reaction characterized by a significant increase of gingival elastase content, infiltration of gingival tissues by elicited cells, and gingival elastic fiber breakdown. These parameters were correlated, and measurement of one of them might be useful for pharmacological studies applied to the treatment of periodontal lesions. An example of results obtained from animals treated by heparine was shown.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/1056-8719(94)90070-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Determination of IL-17, BCL-3 and IκBζ expression levels in the gingival crevicular fluid of psoriasis patients.
Arch Dermatol Res
January 2025
Periodontology Department, Faculty of Dentistry, Van Yüzüncü Yıl University, Van, Turkey.
The purpose of this study was to determine the levels of IL-17, Bcl-3 and IκBζ gene expression in the gingival crevicular fluid (GCF) of psoriatic and healthy individuals and to compare the clinical periodontal parameters in the patient and control groups. A total of 10 psoriasis patients and 2 healthy patients in the control group were included in the analysis for IL-17, Bcl-3, and IκBζ gene expression in the GCF. Periodontal health, gingival index, plaque index, and mobility (using a periotest device) levels were compared between the groups.
View Article and Find Full Text PDFThe association between skin allergy testing and oral squamous cell carcinoma in oral lichen planus: a retrospective cohort study.
Arch Dermatol Res
January 2025
Department of Dermatology, Autoimmune Skin Diseases Clinic, University of Utah Spencer F. Eccles School of Medicine, 30 N Mario Capecchi Drive level 1 South, Salt Lake City, 84132, UT, USA.
There is a reported association between oral contact allergy and oral lichen planus (OLP). Likewise oral squamous cell carcinoma (oSCC) is associated with OLP. It is hypothesized that chronic inflammation may contribute to oSCC risk.
View Article and Find Full Text PDFThe plaque reducing efficacy of oil pulling with sesame oil: a randomized-controlled clinical study.
Clin Oral Investig
January 2025
University Hospital for Conservative Dentistry and Periodontology, Medical University of Innsbruck, Innsbruck, 6020, Austria.
Objectives: To compare the plaque reducing efficacy of oil pulling with sesame oil compared to distilled water in a randomized, controlled, examiner-blinded parallel group study.
Materials And Methods: Forty probands without advanced periodontal disease of the University Hospital for Restorative Dentistry and Periodontology, Medical University of Innsbruck (Austria) were randomized allocated to test- (sesame oil) or control group (distilled water) and asked to pull daily in the morning for eight weeks with their allotted fluid for 15 min. Rustogi Modified Navy Plaque Index (RMNPI) and gingival bleeding index were assessed at baseline and after four and eight weeks.
Surgically facilitated orthodontics with clear aligners for severe malocclusion and gingival recessions.
Clin Adv Periodontics
January 2025
Department of Orthodontics and Dentofacial Orthopedics, Eastman Institute for Oral Health, University of Rochester, Rochester, New York, USA.
Background: Gingival recession defects (GRDs) pose functional and esthetic concerns and may be associated with unfavorable tooth positions. Surgically facilitated orthodontic treatment (SFOT) with clear aligners can be a valuable option for adults with severe malocclusion and GRDs.
Methods: A 28-year-old male presented with severe dental crowding, Class III dental malocclusion, localized tooth crossbites, and tapered maxillary arch.
Unveiling Oral Health Differences: Gingival Health and Hygiene in Children With and Without Cleft Lip and Palate.
Cleft Palate Craniofac J
January 2025
Hospital of Craniofacial Anomalies Rehabilitation, University of São Paulo, Bauru, Brazil.
Objective: To compare the oral hygiene and gingival health of children with and without cleft lip and palate.
Design: Cross-sectional comparative study.
Setting: Institutional tertiary referral hospital.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!