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Left-handedness in asthmatic children.
Pediatr Allergy Immunol
June 2003
Physiology Department, Medical School, University of Thessaly, Larissa, Greece.
Left-handedness has been associated with asthma and allergic disorders. The Geschwind-Behan-Galaburda (GBG) hypothesis could explain this association. In view of previous findings, we investigated the distribution of laterality scores among asthmatic children and controls aged 4-8 years old.
View Article and Find Full Text PDFA twin and family study of the association between immune system dysfunction and dyslexia using blood serum immunoassay and survey data.
Brain Cogn
April 1998
University of Kansas, 3031 Dole Human Development Center, Lawrence, KS 66045, USA.
We conducted a study of the association between developmental reading disability (DRD) and immune disorders (ID) using both survey and immunoassay data in two separate samples of families. One sample was made up of twins and their parents and was ascertained through a population-based sampling scheme. The other sample was a set of extended pedigrees selected for apparent autosomal dominant transmission of DRD.
View Article and Find Full Text PDFComments on immune aspects of the Geschwind-Behan-Galaburda model and of the article of Bryden, McManus, and Bulman-Fleming.
Brain Cogn
November 1994
Département de Psychologie, Université du Québec à Montréal, Canada.
The goal of this article is to reconsider the links among immune disorders, testosterone, and left-handedness made originally by Geschwind and Behan (1982) and by Geschwind and Galaburda (1985). We demonstrate that an excess of testosterone in utero is not a prerequisite for immune disorders, because of its destructive action on thymus, and that allergy and autoimmune disorders are not primarily thymo-dependent but B-lymphocyte-dependent. We furthermore study the HLA proposed by Yeo and Gangestad (1993) and retained by Bryden, McManus, and Bulman-Fleming as a possible variable that could explain, in replacement of testosterone, the link among allergy, asthma, and ulcerative colitis.
View Article and Find Full Text PDFIf you can replicate the handedness-immune disorder effect, the more power to you.
Brain Cogn
November 1994
Segalowitz, Department of Psychology, Brock University, St. Catharines, Ontario, Canada.
Bryden, McManus, and Bulman-Fleming's (1994) meta-analysis of studies examining the Geschwind-Behan-Galaburda hypothesis indicates that the original data set supports the hypothesis significantly more than the body of replication attempts. We present data on 2256 subjects that clearly fail to support the hypothesis and describe practical and statistical reasons suggesting why the original data cannot be easily replicated. A power analysis suggests that to find the effect in a general sample, one should plan to have 17,000 to 40,000 subjects.
View Article and Find Full Text PDFAllergy and the Geschwind-Behan-Galaburda model.
Brain Cogn
November 1994
Department of Internal Medicine, Providence Hospital, Southfield, Michigan.
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