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Arg-73 of the RNA endonuclease MazF in Salmonella enterica subsp. arizonae contributes to guanine and uracil recognition in the cleavage sequence.

J Biol Chem

February 2024

Department of Life Science and Medical Bioscience, Waseda University, Tokyo, Japan; Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan; School of Integrative and Global Majors, University of Tsukuba, Ibaraki, Japan. Electronic address:

The sequence-specific endoribonuclease MazF is widely conserved among prokaryotes. Approximately 20 different MazF cleavage sequences have been discovered, varying from three to seven nucleotides in length. Although MazFs from various prokaryotes were found, the cleavage sequences of most MazFs are unknown.

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