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Streptococcal Toxic Shock Syndrome (STSS) Secondary to Monoarticular Septic Arthritis Leading to Multiorgan Failure in a Patient without Underlying Comorbidities: Emphasizing Early Diagnosis and Management Strategies.
Infect Disord Drug Targets
January 2025
HCA Healthcare Las Palmas/Del Sol Internal Medicine Program.
Background: Streptococcal Toxic Shock Syndrome (STSS) is a life-threatening condition caused by bacterial toxins. The STSS triad encompasses high fever, hypotensive shock, and a "sunburn-like" rash with desquamation. STSS, like Toxic Shock Syndrome (TSS), is a rare complication of streptococcal infec-tions caused by Group A Streptococcus (GAS), Streptococcal pyogenes (S.
View Article and Find Full Text PDFAssessment of interocular symmetry of choroidal vascularity index and thickness in patients with systemic sclerosis: a prospective study.
Front Med (Lausanne)
January 2025
Ophthalmology Department, Medical University of Bialystok, Bialystok, Poland.
Purpose: Systemic sclerosis (SSc) affects blood vessels, internal organs, and skin. In ophthalmology, SSc impacts the choroid. The choroidal vascularity index (CVI) measures the vascular component of the choroid and may serve as a biomarker for the disease staging and prognosis.
View Article and Find Full Text PDFPemphigus vulgaris and lichen planus pigmentosus in an HIV-positive patient.
Indian J Sex Transm Dis AIDS
December 2024
Department of DVL, Mahatma Gandhi Medical College and Research Institute, Puducherry, India.
Pemphigus vulgaris is a rare autoimmune blistering disorder which can occur with other disorder with autoimmune etiology like lichen planus pigmentosus. The concurrence of pemphigus vulgaris and HIV infection has been rarely reported in literature. Here we report a 31 year old patient who came with oral and skin erosions suggestive of pemphigus vulgaris and later developed HIV infection with lichen planus pigmentosus.
View Article and Find Full Text PDFPotential implications of granzyme B in keloids and hypertrophic scars through extracellular matrix remodeling and latent TGF-β activation.
Front Immunol
January 2025
International Collaboration on Repair Discoveries (ICORD) Centre, Vancouver Coastal Health Research Institute (VCHRI), University of British Columbia (UBC), Vancouver, BC, Canada.
Keloid scars (KS) and hypertrophic scars (HS) are fibroproliferative wound healing defects characterized by excessive accumulation of extracellular matrix (ECM) in the dermis of affected individuals. Although transforming growth factor (TGF)-β is known to be involved in the formation of KS and HS, the molecular mechanisms responsible for its activation remain unclear. In this study we investigated Granzyme B (GzmB), a serine protease with established roles in fibrosis and scarring through the cleavage of ECM proteins, as a potential new mediator of TGF-β activation in KS and HS.
View Article and Find Full Text PDFPrediction of potential drug targets and key inhibitors (ZINC67974679, ZINC67982856, and ZINC05668040) against using integrated computational approaches.
Front Vet Sci
January 2025
Department of Zoology, Abdul Wali Khan University, Mardan, Khyber Pakhtunkhwa, Pakistan.
, responsible for flea-borne spotted fever, is a rising zoonotic pathogen posing an increasing global threat due to its expanding geographical distribution. The rise in antibiotic-resistant strains of this pathogen underscores the urgent need for new therapeutic interventions. This study employed a comprehensive subtractive proteomics analysis of the proteome, aiming to identify essential, non-host homologous, and pathogen-specific proteins, which were subsequently evaluated as potential new drug targets.
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