Evaluation of obstructed kidneys by discriminant analysis of 99mTc-MAG3 renograms.

Nuklearmedizin

Laboratory of Biophysics and Bioengineering, Faculty of Medicine, University of Barcelona, Spain.

Published: December 1994

This study sought to develop a method of improving the differential diagnostic between healthy and obstructed kidneys using only parameters derived from the 99mTc-MAG3 renogram. The analysis included data from 46 healthy and 36 obstructed kidney units. The parameters calculated were: mean transit time (MTT), time at 20% of the initial height of the renal retention function (T20) and time to peak of the renogram (TP). A discriminant analysis was carried out to obtain a discriminant function in order to differentiate between the two groups. The best results were obtained using the function: (2.5629 InT20) + (2.1280 In TP) -27.1224 which correctly classified 97.56% of the cases, giving a sensitivity of 94.44% and a specificity of 99.99%.

Download full-text PDF

Source

Publication Analysis

Top Keywords

obstructed kidneys
8
discriminant analysis
8
healthy obstructed
8
evaluation obstructed
4
kidneys discriminant
4
analysis 99mtc-mag3
4
99mtc-mag3 renograms
4
renograms study
4
study sought
4
sought develop
4

Similar Publications

N-acetyl-tryptophan in Acute Kidney Injury after Cardiac Surgery.

J Am Soc Nephrol

January 2025

State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.

Background: Cardiac surgery-associated acute kidney injury is a common serious complication after cardiac surgery. Currently, there are no specific pharmacological therapies. Our understanding of its pathophysiology remains preliminary.

View Article and Find Full Text PDF

Urinary obstruction causes injury to the renal medulla, impairing the ability to concentrate urine, and increasing the risk of progressive kidney disease. However, the regenerative capacity of the renal medulla after reversal of obstruction is poorly understood. To investigate this, we developed a mouse model of reversible urinary obstruction.

View Article and Find Full Text PDF

Chronic kidney disease (CKD) is a disease that affects more than 850 million people. Acute kidney injury (AKI) is a common cause of CKD, and blocking the AKI-CKD transition shows promising therapeutic potential. Herein, we found that butyrolactone I (BLI), a natural product, exerts significant nephroprotective effects, including maintenance of kidney function, inhibition of inflammatory response, and prevention of fibrosis, in both folic acid- and ureteral obstruction-induced AKI-CKD transition mouse models.

View Article and Find Full Text PDF

Background: Despite the substantial burden of obesity in the United States (US), data on the comprehensive range of comorbidities in different age groups is limited. This study assessed the prevalence of various comorbidities among people diagnosed with obesity (as per ICD-10 diagnosis code) across age cohorts and compared how they differ from people without obesity.

Methods: This cross-sectional study analyzed individuals from all four regions (Midwest, Northeast, South, and West) of the US who had continuous insurance coverage from 2018 to 2020, using a large health insurance claims database (Merative™ MarketScan).

View Article and Find Full Text PDF

Surgical outcomes of parathyroidectomy for pre-kidney transplantation versus post-kidney transplantation patients.

World J Surg

January 2025

Collaborative Outcomes Research in Endocrine Surgery (CORES) Lab, Division of Endocrine Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Background: Hyperparathyroidism (HPT) is common in end-stage kidney disease and resolves in less than half of kidney transplant (KT) recipients. The ideal timing of parathyroidectomy (PTX), before or after KT, remains unclear. We sought to understand differences in morbidity and mortality after PTX pre-KT and post-KT.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!