AI Article Synopsis
- The study investigates how FSH (Follicle Stimulating Hormone) affects the depletion of a woman's egg reserve.
- It examines a rare case of a 43-year-old woman with low FSH levels and evaluates the effects of pulsatile GnRH treatment on her hormone levels.
- Findings indicate that despite low FSH levels, her follicular reserve depletes, suggesting FSH can prevent follicle death but doesn’t prevent menopause onset.
Article Abstract
Objective: To investigate the role of FSH in the depletion of follicular reserve in a human being.
Design: Prospective evaluation of a very rare case.
Setting: Academic research environment.
Patient: A 43-year-old woman with primary hypogonadotropic hypoestrogenic amenorrhea, with very low levels of plasma FSH throughout her life.
Interventions: Pulsatile GnRH was administered IV at the dose of 4 micrograms every 90 minutes for 20 days. Blood samples were collected every 3 to 4 days.
Main Outcome Measures: Plasma levels of E2, FSH, and LH.
Results: During the 20 days of treatment there was no increase in E2 plasma levels. On the contrary, FSH and LH levels began to rise after 3 days and reached postmenopausal levels within 20 days.
Conclusions: Depletion of follicular reserve may occur also when the levels of FSH are very low throughout a woman's life. Thus FSH seems only able to rescue follicles from atresia without interfering with the onset of menopause.
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Source |
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| http://dx.doi.org/10.1016/s0015-0282(16)57445-7 | DOI Listing |
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