AI Article Synopsis
- The study aimed to investigate whether higher serum gastrin levels are associated with colorectal tumors, which could influence screening and treatment methods.
- Researchers analyzed fasting serum gastrin levels in 91 colorectal cancer patients, 89 with colorectal polyps, and 101 individuals with normal colonoscopy results, spanning from 1983 to 1992.
- Results indicated that median serum gastrin concentrations were similar across all groups, with no significant differences found, suggesting no link between gastrin levels and colorectal conditions.
Article Abstract
Purpose: Confirmation of an association between elevated serum gastrin concentrations and presence of colorectal tumors would have important implications with regard to screening procedures and therapeutic strategies.
Methods: We compared fasting serum gastrin concentrations of patients with colorectal cancer (n = 91; mean age, 66 (range, 35-87) years), colorectal polyps (n = 89; mean age, 61 (range, 38-86) years), or a normal colonoscopy (n = 101; mean age, 62 (range, 34-82) years) in the period between 1983 and 1992.
Results: Median serum gastrin concentrations were, respectively, 20, 20, and 21 pmol/liter (not significant). We were unable to find a relation with histology of the polyp, presence or severity of dysplasia, and extent of cancer.
Conclusions: This large study fails to show any difference in serum gastrin concentrations among the three studied groups.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF02052446 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!