Intake and fecal excretion of PCDDs, PCDFs, HCB and PCBs (IUPAC Nos. 138, 153, 180) were measured in a breast-fed and a formula-fed infant at the age of 1 and 5 months. As expected, the intake of these compounds was clearly higher in the breast-fed infant. In this baby an almost complete absorption was observed for lower chlorinated PCDDs and PCDFs and also for HCB and PCBs, whereas for hepta- and octachlorinated PCDDs and PCDFs fecal excretion was considerably higher (from 20% up to nearly 100% of the intake). Due to low concentrations in diet and feces of the formula-fed infant an evaluation was possible only for a few compounds at the age of 5 months. These values were in the same range when compared with those of the breast-fed infant. For collection of feces new cotton diapers were used which were pre-extracted in order to reduce the levels of polychlorinated compounds. Unexpectedly, after washing the tissue a much higher contamination was observed which made a calculation of fecal excretion rates in the formula-fed infant at the age of 1 month impossible.
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http://dx.doi.org/10.1016/0045-6535(94)90395-6 | DOI Listing |
BMC Pediatr
March 2025
Department of Clinical Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
Background: Globally, gastroenteritis stands as a primary contributor to child mortality, annually taking the lives of 3 million children under the age of 5 years. Rotavirus, a major factor in viral diarrhea among children aged 6 months to 2 years, presents with severe symptoms such as watery diarrhea and vomiting. Although mortality rates have decreased due to supportive care and vaccines, promising alternatives like N-acetylcysteine (NAC) show potential benefits in laboratory studies, indicating a possible supplementary strategy for managing rotavirus infections by reducing the duration and antigen excretion in feces.
View Article and Find Full Text PDFJ Agric Food Chem
March 2025
Department of Food Science and Engineering, Institute of Food Safety and Nutrition, Guangdong Engineering Technology Center of Food Safety Molecular Rapid Detection, Jinan University, Guangzhou 510632, Guangdong, China.
The study is to explore the biosynthesis of cyanidin-3-glucoside-4-vinylcatechol (C3G_VC) through -fermented caffeic acid and cyanidin-3-glucoside (C3G) extract (molar ratio = 1:30) in the model medium. C3G_VC was isolated and purified by a venusil ASB-C18 column with a medium-pressure liquid chromatography (MPLC) system. The chemical structure of C3G_VC was identified by high-performance liquid chromatography (HPLC), which showed the maximum absorption wavelength of 505.
View Article and Find Full Text PDFJ Anim Sci
March 2025
Department of Animal Biosciences, University of Guelph, Guelph, Ontario, Canada.
This study investigated the effects of up to 45% inclusion of whole pulse ingredients in grain-free (GF) diets on the excretion of bile acids (BA) and other fecal metabolites in healthy large-breed dogs. Twenty-eight adult Siberian Huskies were fed one of four experimental diets formulated to meet the same macronutrient profiles for 20 weeks: 1) grain-inclusive diet with 45% corn (Ctl), 2) GF diet with 15% pulses (Pulse15), 3) GF diet with 30% pulses (Pulse30), 4) GF diet with 45% pulses (Pulse45). All diets included chicken meal and pea starch.
View Article and Find Full Text PDFChem Biodivers
March 2025
ISF College of Pharmacy, Pharmaceutical Chemistry, GT Road, Ghal Kalan, 142001, Moga, INDIA.
In the present work, we have explored the importance of the imidazole ring and its importance in drug discovery, citing the key approvals in the present decade (2013-2024). The pharmacological attribution for the approved drugs revealed that out of 20 approved drugs, 45% of the approvals were made as anti-infectives, followed by approvals under the category of genetic and metabolic disorders, sexual endocrine disorders, anticancer, and to treat blood pressure, gastrointestinal disorders, and neurological conditions. The excretion pattern of these drugs revealed that the drugs are majorly excreted via the fecal route.
View Article and Find Full Text PDFJ Dairy Sci
March 2025
Danisco Animal Nutrition & Health (IFF), 2342 BH Oegstgeest, the Netherlands.
Undigested P and N are excreted and contribute to the environmental impacts of dairy farming. Degradation of phytate in the rumen has been shown to be high but variable, leading to incomplete phytate-P utilization and resultant antinutritional impacts of phytate along the gastrointestinal tract. We investigated the effect of a novel bacterial 6-phytase (PhyG) on the apparent total-tract digestibility (ATTD) and excretion of DM, phytate-P (PP), P, CP and NDF in lactating dairy cows.
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