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screening for toxicity-modulating drug interactions identifies antagonism that protects against ototoxicity in zebrafish.
Front Pharmacol
March 2024
Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States.
Ototoxicity is a debilitating side effect of over 150 medications with diverse mechanisms of action, many of which could be taken concurrently to treat multiple conditions. Approaches for preclinical evaluation of drug-drug interactions that might impact ototoxicity would facilitate design of safer multi-drug regimens and mitigate unsafe polypharmacy by flagging combinations that potentially cause adverse interactions for monitoring. They may also identify protective agents that antagonize ototoxic injury.
View Article and Find Full Text PDFIncreased risk of hearing loss associated with macrolide use: a systematic review and meta-analysis.
Sci Rep
January 2024
Department of Biomedical Informatics, College of Medicine, Konyang University, Daejeon, Republic of Korea.
Article Synopsis
- A systematic review and meta-analysis was conducted to evaluate the relationship between macrolide antibiotics and the risk of hearing loss, tinnitus, and ototoxicity, utilizing a comprehensive search of various medical databases and clinical trials up to May 2023.
- The analysis included a total of 13 studies involving over 1 million patients, specifically comparing those who used macrolides like azithromycin and erythromycin against control groups receiving placebos or other antibiotics.
- Findings indicated that the overall risk of hearing loss associated with macrolide use was statistically significant, showing a pooled odds ratio of 1.25, suggesting a 25% increased risk compared to controls.
Ototoxicity is a debilitating side effect of over 150 medications with diverse mechanisms of action, many of which could be taken concurrently to treat multiple conditions. Approaches for preclinical evaluation of drug interactions that might impact ototoxicity would facilitate design of safer multi-drug regimens and mitigate unsafe polypharmacy by flagging combinations that potentially cause adverse interactions for monitoring. They may also identify protective agents that antagonize ototoxic injury.
View Article and Find Full Text PDFOtotoxicity of Non-aminoglycoside Antibiotics.
Front Neurol
March 2021
Department of Otolaryngology, Southern Illinois University School of Medicine, Springfield, IL, United States.
It is well-known that aminoglycoside antibiotics can cause significant hearing loss and vestibular deficits that have been described in animal studies and in clinical reports. The purpose of this review is to summarize relevant preclinical and clinical publications that discuss the ototoxicity of non-aminoglycoside antibiotics. The major classes of antibiotics other than aminoglycosides that have been associated with hearing loss in animal studies and in patients are discussed in this report.
View Article and Find Full Text PDFAuditory Cinchonism in COVID Era.
Ear Nose Throat J
November 2020
Department of Otorhinolaryngology, Faculty of Medicine, 65300University of Malaya, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia.
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