We evaluated the effect of smoking on the risk of cervical dysplasia in a large case-control study, obtaining smoking information from a mail questionnaire. We observed higher risks with increasing numbers of cigarettes smoked, but not with longer duration of smoking. The risk for ex-smokers was between those of current smokers and nonsmokers and was lower for women who had stopped more than 10 years ago than for those who had quit more recently. Starting to smoke at an early age did not increase the risk of cervical dysplasia.
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http://dx.doi.org/10.1097/00001648-199411000-00011 | DOI Listing |
Clin Cancer Res
January 2025
University Medical Center Groningen, Groningen, Netherlands.
Purpose: Human papillomavirus (HPV) infection is the major cause of (pre)malignant cervical lesions. We previously demonstrated that Vvax001, a replication-incompetent Semliki Forest virus (SFV) vaccine encoding HPV type 16 (HPV16) E6 and E7, induced potent anti-E6 and -E7 cytotoxic T-cell responses. Here, we investigated the clinical efficacy of Vvax001 in patients with HPV16-positive cervical intraepithelial neoplasia grade 3 (CIN3).
View Article and Find Full Text PDFCan Fam Physician
January 2025
Family medicine and emergency medicine physician practising in the South Shore region of Nova Scotia.
Objective: To provide primary care providers (PCPs) with an approach for diagnosing and managing endocervical polyps, detailing a procedural technique for cervical polypectomy and outlining key information on when to refer to a gynecologist.
Sources Of Information: This review and approach are based on the second author's clinical practice and available literature from 1994 to 2023.
Main Message: Cervical polyps are commonly asymptomatic and benign, but can cause intermenstrual and postcoital bleeding.
Cureus
December 2024
Department of Pediatrics, Japanese Red Cross Wakayama Medical Center, Wakayama, JPN.
Acute ischemic stroke, a medical emergency caused by reduced cerebral blood flow, results in brain cell damage. While commonly associated with older individuals, strokes can also occur in young and middle-aged adults, posing significant socio-economic and health challenges due to the long-term impact of the condition. This poses significant socio-economic and health challenges because stroke is a leading cause of disability and mortality.
View Article and Find Full Text PDFBMC Cancer
January 2025
Department of Pharmacology and Public Health, Faculty of Medicine, The Hashemite University, Zarqa, 13133, Jordan.
Background: Oncogene-Induced Senescence (OIS) is a form of senescence that occurs as a consequence of oncogenic overstimulation and possibly infection by oncogenic viruses. Whether senescence plays a role in the pathogenesis of cervical cancer (CC) is not well understood. Moreover, whether cervical epithelial cells that are part of the premalignant cervical intraepithelial neoplasia (CIN), exhibit markers of OIS in Human Papillomavirus (HPV)-infected tissue, has not been investigated.
View Article and Find Full Text PDFBMC Womens Health
January 2025
Hunan Provincial Key Laboratory of Regional Hereditary Birth Defects Prevention and Control, Changsha, China.
Background: Persistent infection with high-risk human papillomavirus (HPV) is a significant risk factor for cervical cancer. HPV typing and cytology are conducted in women of appropriate age to assess the risk of cervical lesions and to guide the need for further diagnostic procedures such as colposcopy, cervical biopsy, or treatment. This article explores methods to predict the risks of high-grade precancerous cervical lesions based on high-risk HPV typing.
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