[Middle molecule levels in patients with spinal cord trauma].

The levels of medium-weight molecules was estimated in the serum of 46 patients, including 36 patients with cerebrospinal injury and 10 patients with craniocerebral injury, 5 healthy volunteers were in the control group. The toxic metabolites studied were markedly increased in all these patients as compared with the controls. However, the highest alterations were detected in the patients with cerebrospinal injury in early periods of observation, thus suggesting that the trauma and duration might be responsible for intoxication manifestations. Estimation of the levels of medium-weight molecules in blood may be used in evaluation of the degree of intoxication in spinal patients.