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The Association of TSLP and IL-4 with Patient-Reported Outcome Measures in Chronic Rhinosinusitis with Nasal Polyps.
Am J Rhinol Allergy
January 2025
Division of Otolaryngology - Head & Neck Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Background: Thymic stromal lymphopoietin (TSLP) plays an important role in mediating the type-2-inflammatory response. This study examined how TSLP and interleukin (IL)-4 levels in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) correlated with clinical and postoperative outcomes.
Methods: Solid-phase sandwich ELISA was used to analyze TSLP and IL-4 levels in mucus (n = 47), plasma (n = 17), polyp (n = 30), inferior (n = 25), and middle (n = 26) turbinate tissue collected during functional endoscopic sinus surgery (FESS) in CRSwNP patients (n = 76) and controls (n = 11).
[Intrathyroid thymic carcinoma: report of a case].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
January 2025
Intrathyroid thymic carcinoma（ITTC） is a rare thyroid tumor that lacks typical clinical manifestations and imaging features, making preoperative diagnosis challenging.The primary treatment for ITTC is radical surgery; however, the effectiveness of adjuvant radiotherapy and chemotherapy post-surgery is not well-established. This paper presents a case of ITTC , analyzing the clinical data and correlating it with the literature to explore the clinical manifestations, diagnostic approach, treatment, and prognosis of ITTC.
View Article and Find Full Text PDFSubmandibular Ectopic Thymic Mass in a 6-Month-Old Infant.
World J Nucl Med
December 2024
Department of Molecular Imaging and Therapeutics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States.
Infant ectopic cervical thymus is a relatively uncommon diagnosis and, in many cases, subclinical. If not subclinical, it may present as a palpable swelling or with compressive symptoms (i.e.
View Article and Find Full Text PDFHHV-6B, HHV-7, and B19V Are Frequently Found DNA Viruses in the Human Thymus but Show No Definitive Link with Myasthenia Gravis.
J Infect Dis
December 2024
Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
Myasthenia gravis (MG) is a rare autoimmune disorder characterised by muscle weakness resulting from autoantibody-mediated disruption of the neuromuscular junction. Notably, it is also frequently associated with thymic pathology. This study explores the relationship between MG and DNA viruses in the thymus, employing targeted NGS and qPCR to analyse thymic tissue samples from both MG patients and healthy controls.
View Article and Find Full Text PDFComplete surgical resection of a thymic cyst located in the middle mediastinum with extension into the carina through a neck incision: A case report study.
Int J Surg Case Rep
January 2025
Professor in Thoracic Surgery, Damascus Hospital, Damascus, Syria.
Introduction And Significance: Thymic cysts are rare, located in the middle mediastinum, and are often asymptomatic and discovered incidentally. When they are symptomatic, the symptoms are often due to the effect of the mass, and complete surgical excision is preferred to avoid the risk of complications following their persistence.
Case Presentation: We present a case of a patient who had recurrent dyspnea and was later diagnosed with a cystic formation in the middle mediastinum by radiological investigations and successfully treated through a neck incision and completely resected.
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