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Pantothenate kinase 4 controls skeletal muscle substrate metabolism.
Nat Commun
January 2025
Department of Molecular Physiology of Exercise and Nutrition, German Institute of Human Nutrition (DIfE), Potsdam-Rehbruecke, Nuthetal, Germany.
Article Synopsis
- Metabolic flexibility in skeletal muscle is crucial for healthy glucose and lipid metabolism, and its dysfunction can lead to metabolic diseases.
- Exercise improves metabolic flexibility and helps identify mechanisms that support metabolic health.
- The study reveals that pantothenate kinase 4 (PanK4) is vital for muscle metabolism, as its deletion disrupts fatty acid oxidation and elevates harmful acetyl-CoA levels, which lead to glucose intolerance, while increasing PanK4 enhances glucose uptake and lowers acetyl-CoA.
Characterization of acidic lysine acylations in mycobacteria.
Front Microbiol
December 2024
School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Article Synopsis
- Protein acetylation is a widely studied post-translational modification, and recent research has identified three new forms: lysine malonylation, succinylation, and glutarylation, which mainly affect energy metabolism in diseases caused by Mycobacterium pathogens.
- Methods involved using high-affinity antibody enrichment and LC-MS/MS analysis to characterize these new lysine modifications and assess their functional impacts in certain proteins.
- Results showed significant global substrate characterization for these acylations, revealing connections to ribosomal function and various metabolic pathways, highlighting their importance in cellular processes.
Overview of resveratrol properties, applications, and advances in microbial precision fermentation.
Crit Rev Biotechnol
November 2024
CEB - Centre of Biological Engineering, University of Minho, Braga, Portugal.
Resveratrol is an antioxidant abundant in plants like grapes and peanuts and has garnered significant attention for its potential therapeutic applications. This review explores its chemical attributes, stability, and solubility, influencing its diverse applications and bioavailability. Resveratrol's multifaceted therapeutic roles encompass: antioxidant, cardioprotective, anti-inflammatory, neuroprotective, anti-aging, and anticancer properties.
View Article and Find Full Text PDFTargeting acetyl-CoA carboxylases for the treatment of MASLD.
J Lipid Res
December 2024
Department of Biomedicine, Biotechnology and Public Health, Biomedical Research and Innovation Institute of Cadiz (INiBICA), Faculty of Medicine, University of Cadiz, Cadiz, Spain. Electronic address:
Hepatic accumulation of triglycerides is a hallmark feature of metabolic dysfunction-associated steatotic liver disease (MASLD). Growing evidence indicates that increased rates of de novo lipogenesis (DNL) are one of the earliest metabolic changes promoting hepatic steatosis in the onset of MASLD. The first step in DNL is catalyzed by acetyl-CoA carboxylases (ACC), which mediate the conversion of acetyl-CoA into malonyl-CoA.
View Article and Find Full Text PDFTranscriptome analysis of tilapia streptococcus agalactiae in response to baicalin.
Genes Genomics
January 2025
Collaborative Innovation Center of Marine Science and Technology, Hainan Provincial Key Laboratory for Tropical Hydrobiology and Biotechnology, School of Marine Biology and Fisheries, Hainan University, Haikou, 570228, P.R. China.
Article Synopsis
- S. agalactiae is a harmful bacterial pathogen in aquatic animals, and baicalin has been found to significantly inhibit its β-hemolytic/cytolytic activity, which is crucial for its virulence.
- This study investigated how baicalin works by analyzing changes in gene expression after bacteria were treated with it, identifying 10 differentially expressed genes (DEGs) related to various biological functions and pathways.
- The findings suggest that baicalin disrupts key metabolic processes and pathways necessary for producing virulence factors, ultimately inhibiting S. agalactiae's harmful effects.
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