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A variable course of Cushing's disease in a 7 year old: diagnostic dilemma.
J Pediatr Endocrinol Metab
November 2018
Fellow Pediatric Endocrinology, Indraprastha Apollo Hospital, New Delhi, India.
Background Cushing's syndrome (CS) or hypercortisolism results from disruption of the hypothalamus-pituitary-adrenal (HPA) axis with the resultant increase in the circulating serum and urinary cortisol levels and lack of cortisol circadian rhythm. The resultant effects cause the physical manifestation of hypercortisolism. The appearance of Cushing's disease in children is insidious, the most common features being growth failure, obesity, early puberty and facial appearance.
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