Although severe infection caused by methicillin-resistant Staphylococcus aureus (MRSA) has become a serious social problem in medical facilities, it is relatively uncommon in the urological field. It is supposed that MRSA in the urine is asymptomatic and MRSA urinary colonization is not likely to occur compared with the other Staphylococci. We report a case of sepsis caused by MRSA that occurred in the patient following retropubic prostatectomy. He had had a urinary catheter indwelt and had received anti-bacterial agents before the operation. Factors such as the continuing use of antibiotics and urinary catheterization could contribute to MRSA infections especially following open surgery. Therefore careful management seems important for such patients.

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