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Light People: Professor Aydogan Ozcan.

Light Sci Appl

October 2021

Light Publishing Group, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, 3888 Dong Nan Hu Road, Changchun, 130033, China.

In 2016, the news that Google's artificial intelligence (AI) robot AlphaGo, based on the principle of deep learning, won the victory over lee Sedol, the former world Go champion and the famous 9th Dan competitor of Korea, caused a sensation in both fields of AI and Go, which brought epoch-making significance to the development of deep learning. Deep learning is a complex machine learning algorithm that uses multiple layers of artificial neural networks to automatically analyze signals or data. At present, deep learning has penetrated into our daily life, such as the applications of face recognition and speech recognition.

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DNA Barcode Technology and Its Application Prospects in Forensic Medicine.

Fa Yi Xue Za Zhi

August 2020

School of Forensic Medicine, Zunyi Medical University, Zunyi 563000, Guizhou Province, China.

Traditional species identification has gone through five stages -- morphology, cytology, biochemistry, immunology and molecular biology. At present, the use of DNA technology for species identification has become a research hotspot. In the use of DNA for species identification, the presentation and application of DNA barcode is of epoch-making significance.

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Most of our current knowledge about the gene regulation of pathogen comes from studies with in vitro conditions that mimic their host environments, revealing many types of virulence genes and their regulatory network. Recent advances in DNA sequencing and techniques for transcriptome analysis allow us to identify pathogenic genes specifically expressed in vivo. Analyses for gene expression of pathogens in response to the host environment, including immune response and change of bacterial flora during infection, provide clues to understanding the underlying events to establish the infectious diseases.

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On the occasion of the 150th anniversary of the death of Franz von Paula Gruithuisen, the authors present his life and work. His most significant work in the fields of urology and lithotrity is examined, with special emphasis on the development of the latter field. He published his epoch-making historic study in 1813 in the Journal of Medicine and Surgery (Medicinisch-Chirurgische Zeitung).

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