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Rhodotorula mucilaginosa: a new potential human pathogen found in the ciliate Paramecium bursaria.
Protoplasma
January 2025
Core Facility Center "Cultivation of Microorganisms", Saint-Petersburg State University, Saint-Petersburg, Russian Federation.
Ciliates often form symbiotic associations with other microorganisms, both prokaryotic and eukaryotic. We are now starting to rediscover the symbiotic systems recorded before molecular analysis became available. Here, we provide a morphological and molecular characterization of a symbiotic association between the ciliate Paramecium tritobursaria and the yeast Rhodotorula mucilaginosa (syn.
View Article and Find Full Text PDFAutologous DNA mobilization and multiplication expedite natural products discovery from bacteria.
Science
December 2024
Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany.
The transmission of antibiotic-resistance genes, comprising mobilization and relocation events, orchestrates the dissemination of antimicrobial resistance. Inspired by this evolutionarily successful paradigm, we developed ACTIMOT, a CRISPR-Cas9-based approach to unlock the vast chemical diversity concealed within bacterial genomes. ACTIMOT enables the efficient mobilization and relocation of large DNA fragments from the chromosome to replicative plasmids within the same bacterial cell.
View Article and Find Full Text PDFUnraveling the Clinical Quandary: Cryptic Tuberculosis or Splenogonadal Malignancy?
Cureus
October 2024
Radiodiagnosis, Pt. Jawahar Lal Nehru Memorial Medical College, Raipur, IND.
Tuberculosis continues to persist as a significant health problem in multiple parts of the world despite global efforts to eradicate it. A high variability in the clinical manifestation hinders the early diagnosis. Atypical presentations like "cryptic tuberculosis" lack classic clinical and radiological features of the disease and can mimic metastatic cancer, posing a diagnostic challenge.
View Article and Find Full Text PDFComparative genome analysis and the genome-shaping role of long terminal repeat retrotransposons in the evolutionary divergence of fungal pathogens Blastomyces dermatitidis and Blastomyces gilchristii.
G3 (Bethesda)
November 2024
Microbiology and Laboratory Services, Public Health Ontario, 661 University Avenue, Toronto, ON M5G 1M1, Canada.
Article Synopsis
- Blastomyces dermatitidis and Blastomyces gilchristii are closely related fungi that cause a serious disease called blastomycosis, which primarily affects the lungs but can spread throughout the body.
- Genetic analysis reveals that while the species look alike, they differ significantly in their genome size, with B. gilchristii being larger and having more retrotransposons, particularly Gypsy elements.
- These differences in genetic makeup and retrotransposon content may have contributed to their speciation through processes that lead to reproductive isolation.
Genomic epidemiology uncovers the timing and origin of the emergence of mpox in humans.
medRxiv
June 2024
African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.
Article Synopsis
- Nigeria reported its first mpox cases in nearly 40 years five years before the 2022-2023 outbreak, with ongoing human-to-human transmission driving the epidemic.
- Researchers analyzed 112 mpox virus genomes from Nigeria (2021-2023) and traced the lineage back to its emergence around July 2014 from southern Nigeria, specifically Rivers State.
- The study also found that human-to-human transmission significantly increased the virus's evolutionary rate and emphasized the importance of better pathogen surveillance and response strategies.
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