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[Aspirin reduces lung inflammatory response in acute lung injury/acute respiratory distress syndrome: a Meta-analysis based on animal experiments].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
December 2024
Department of Intensive Care Unit, the Affiliated Hospital of Guizhou Medical University, Guiyang 550004, Guizhou, China. Corresponding author: Shen Feng, Email:
Objective: To systematically evaluate the impact of aspirin on the pulmonary inflammatory response in animal models of acute lung injury/acute respiratory distress syndrome (ALI/ARDS).
Methods: Experimental research on aspirin therapy or prevention of ALI/ARDS in animal models were searched in PubMed, Web of Science, Cochrane library, Embase, China biology medicine, CNKI, Wanfang, VIP. The search time limit was from the establishment of the database to July 17, 2023.
Extracellular vesicles from platelet-poor plasma possess anti-inflammatory and anti-catabolic effects in chondrocytes stimulated with IL-1β or synovial membrane-conditioned media.
J Orthop Surg Res
December 2024
Associated Tissue Bank, Faculty of Medicine, P.J. Safarik University and L. Pasteur University Hospital in Kosice, Tr. SNP 1, Kosice, 04011, Slovakia.
Article Synopsis
- Osteoarthritis (OA) is common and currently lacks effective treatments that can both modulate the immune response and repair cartilage, prompting research into extracellular vesicles (EVs) from blood-derived products like platelet poor plasma (PPP).
- This study examined how PPP-derived EVs affect OA chondrocytes in a lab setting, revealing that these EVs possess anti-inflammatory properties and can significantly reduce the expression of certain inflammatory genes associated with OA.
- The findings suggest that PPP-EVs can potentially be developed as a new type of treatment for OA, offering promise for better management of the disease in the future.
Beyond Hormones: A Systematic Review of the Risk of Cardiovascular Diseases in Polycystic Ovary Syndrome.
Cureus
November 2024
Internal Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, IND.
Polycystic ovary syndrome (PCOS) is a common endocrinopathy among women in the reproductive age group. PCOS is defined by the Rotterdam criteria, which include hyperandrogenism, oligo-anovulation, and polycystic ovaries on ultrasound. The common symptoms are irregular or absent periods, acne, hirsutism, and alopecia androgenica.
View Article and Find Full Text PDFInterleukin-1 receptor-dependent and -independent caspase-1 activity in retinal cells mediated by receptor interacting protein 2.
Front Cell Dev Biol
October 2024
Department of Physiology, Michigan State University, East Lansing, MI, United States.
Introduction: Inflammation and cell death play an important role in the pathogenesis of diabetic retinopathy. Previously we observed sustained activation of pro-inflammatory caspase-1 in retinas of diabetic animals and patients. In this study, we aimed to look at mechanisms underlying chronic caspase-1 activation and .
View Article and Find Full Text PDFCaspase-1-dependent spatiality in triple-negative breast cancer and response to immunotherapy.
Nat Commun
October 2024
Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Tumor immune microenvironment (TIME) spatial organization predicts outcome and therapy response in triple-negative breast cancer (TNBC). An immunosuppressive TIME containing elevated tumor-associated macrophages (TAM) and scarce CD8+ T cells is associated with poor outcome, but the regulatory mechanisms are poorly understood. Here we show that ETS1-driven caspase-1 expression, required for IL1β processing and TAM recruitment, is negatively regulated by estrogen receptors alpha (ERα) and a defining feature of TNBC.
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