Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1176/ps.45.10.973 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Metastatic Prostate Cancers with BRCA2 versus ATM Mutations Exhibit Divergent Molecular Features and Clinical Outcomes.
Clin Cancer Res
July 2023
Masonic Cancer Center, University of Minnesota-Twin Cities, Minneapolis, Minnesota.
Purpose: In patients with metastatic prostate cancer (mPC), ATM and BRCA2 mutations dictate differences in PARPi inhibitor response and other therapies. We interrogated the molecular features of ATM- and BRCA2-mutated mPC to explain the divergent clinical outcomes and inform future treatment decisions.
Experimental Design: We examined a novel set of 1,187 mPCs after excluding microsatellite-instable (MSI) tumors.
ALAN is a computational approach that interprets genomic findings in the context of tumor ecosystems.
Commun Biol
April 2023
Department of Medicine, University of Minnesota Masonic Cancer Center, Minneapolis, MN, USA.
Gene behavior is governed by activity of other genes in an ecosystem as well as context-specific cues including cell type, microenvironment, and prior exposure to therapy. Here, we developed the Algorithm for Linking Activity Networks (ALAN) to compare gene behavior purely based on patient -omic data. The types of gene behaviors identifiable by ALAN include co-regulators of a signaling pathway, protein-protein interactions, or any set of genes that function similarly.
View Article and Find Full Text PDFIntegrative molecular analyses define correlates of high B7-H3 expression in metastatic castrate-resistant prostate cancer.
NPJ Precis Oncol
November 2022
Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
B7-H3 (CD276) is an immune checkpoint overexpressed in prostate cancer with minimal expression in normal tissues and associated with poor prognosis, making it an excellent therapy target. We interrogated B7-H3 expression and its regulation in metastatic castration-resistant prostate cancer (mCRPC). We found greater expression of B7-H3 transcript relative to other immunotherapy targets (CTLA-4, PD-L1/2), including in tumors that lacked expression of prostate-specific membrane antigen (PSMA).
View Article and Find Full Text PDFAssessment of Materials to Prevent Sutures Cutting Through Atrophic Skin.
Dermatol Surg
December 2020
Bennett Surgery Center, Santa Monica, California.
Background: Sutures can tear through thin skin, especially in the elderly. To reinforce thin skin, several materials have been suggested through which sutures may be placed.
Objective: To evaluate the relative tear-through resistance to suture provided by various materials applied to a skin substitute.
Patients' views and experiences of technology based self-management tools for the treatment of hypertension in the community: A qualitative study.
BMC Fam Pract
September 2015
Centre for Rural Health, University of Aberdeen, Inverness, Scotland.
Background: Patients with hypertension in the community frequently fail to meet treatment goals. The optimal way to organize and deliver care to hypertensive patients has not been clearly identified. The powerful on-board computing capacity of mobile devices, along with the unique relationship individuals have with newer technologies, suggests that they have the potential to influence behaviour.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!