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Anti-SRP Antibodies and Myocarditis in Systemic Sclerosis Overlap Syndrome with Immune-Mediated Necrotizing Myositis (IMNM).
Medicina (Kaunas)
October 2024
Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Article Synopsis
- - Overlap syndrome of systemic sclerosis and idiopathic inflammatory myopathies is becoming more common, but its link with immune-mediated necrotizing myositis is not well-documented, requiring careful differentiation for proper treatment and prognosis.
- - Anti-signal recognition particle (anti-SRP) antibodies are crucial in diagnosing immune-mediated necrotizing myopathy, causing muscle damage and weakness, while their relationship with cardiac issues remains inconclusive, complicating potential management.
- - Diagnosing heart complications like myocarditis in these patients is challenging, often relying on cardiac imaging rather than biopsies, and this paper explores the issues of accurately diagnosing and treating diseases related to collagen and anti-SRP antibodies.
Diabetes Myonecrosis: A Debilitating Complication in an Indigenous Young Woman With Long Standing Type 1 Diabetes Mellitus.
Case Rep Endocrinol
September 2024
Department of Diabetes and Endocrinology Townsville University Hospital, Townsville, Australia.
Article Synopsis
- A 24-year-old Indigenous Australian woman with poorly controlled type 1 diabetes presented with swelling and pain in her thigh for three months.
- Tests revealed an ongoing inflammatory state, but infectious and autoimmune causes were ruled out.
- The case emphasizes diabetic myonecrosis as a rare but serious complication of diabetes, underscoring the importance of good blood sugar management to prevent such issues.
Fatal Clostridium septicum gas gangrene complicating ECMO: case report and review of literature.
Access Microbiol
August 2024
Critical Care Unit, Department of Anaesthesia, Critical Care and Perioperative Medicine, University Hospital of Rennes, Rennes, France.
Article Synopsis
- Gas gangrene is a serious infection caused by a specific type of bacteria, and it can occur either due to trauma or spontaneously without an apparent injury.
- This report presents a case where a patient suffered from a severe form of gas gangrene following cardiac arrest and needed advanced life support through ECMO.
- The study also highlights the complications of diagnosing and treating spontaneous gas gangrene while emphasizing the importance of appropriate antibiotic treatment before starting ECMO.
Clostridial Myonecrosis: A Comprehensive Review of Toxin Pathophysiology and Management Strategies.
Microorganisms
July 2024
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Article Synopsis
- Clostridial myonecrosis, or gas gangrene, is a serious and fast-moving bacterial infection that affects muscles and soft tissues, with around 1000 cases annually in the U.S. and even more in developing nations.
- It is primarily caused by the Clostridium bacteria, which thrive in low-oxygen environments from injuries, leading to two types: traumatic (from injuries) and spontaneous (in immunocompromised individuals).
- Symptoms include severe pain and swelling, rapid tissue death, and systemic effects if untreated; diagnosis relies on clinical assessments and imaging, while treatment consists of surgery, antibiotics, and possibly hyperbaric oxygen therapy.
Diabetic myonecrosis complicated by emphysematous pyomyositis and abscess caused by Escherichia coli: a case report.
J Med Case Rep
July 2024
Department of Infectious Diseases, Inflammation Center, Helsinki University Hospital, Helsinki, Finland.
Background: Necrotizing myopathies and muscle necrosis can be caused by immune-mediated mechanisms, drugs, ischemia, and infections, and differential diagnosis may be challenging.
Case Presentation: We describe a case of diabetic myonecrosis complicated by pyomyositis and abscess caused by Escherichia coli. A white woman in her late forties was admitted to the hospital with a 1.
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