AI Article Synopsis
- The study investigated the presence of copper and zinc superoxide dismutase (Cu, Zn-SOD) in the adenohypophysis and pituitary adenomas using immunohistochemical techniques.
- The sample included thirteen functioning adenomas (such as prolactinomas and growth hormone secreting tumors), five nonfunctioning adenomas, and three normal adenohypophyseal specimens for comparison.
- Results showed that while Cu, Zn-SOD was found in both normal and tumor cells, the levels were significantly higher in normal adenohypophyseal cells compared to adenoma cells, with no notable differences between functioning and non-functioning adenomas.
Article Abstract
A location of copper and zinc- superoxide dismutase (Cu, Zn-SOD) in adenohypophysis and pituitary adenomas was examined with immunohistochemical technique. Pituitary adenomas include thirteen functioning, five nonfunctioning; functioning adenomas consist seven prolactinomas, four growth hormone (GH) secreting, two adrenocorticotropic hormone (ACTH) secreting adenomas. Three specimens of normal adenohypophysis were used for control study. The Cu, Zn-SOD was localized diffusely in the cytoplasm of normal adenohypophyseal cells and the tumor cells. Sometimes immunoreactive products of Cu, Zn-SOD revealed in the cytoplasm of endothelial cell, neutrophil, macrophage and the cell membrane of erythrocyte in the vessels. The content of Cu, Zn-SOD in normal adenohypophyseal cells and pituitary adenomas was markedly higher in normal cells than adenoma cells. No significant difference of the SOD content was observed not only in non-functioning adenoma but also in functioning adenoma cells including PRL, GH and ACTH cells.
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