Several 1-[quinolyl(4)]-1,2,3-triazoles were synthesized by 1,3-dipolar cycloaddition of 4-azidoquinolines with activated methylene compounds. The synthesized compounds, tested for antiinflammatory and analgesic activities, resulted moderately active as antiinflammatories, but with a very interesting analgesic activity, sometimes higher than that of indomethacin, used as reference drug. Some of the triazole derivatives were evaluated also as antimicrobial, but none of them exhibited activity.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
antiinflammatory analgesic
8
1-[quinolyl4]-123-triazoles synthesis
4
synthesis evaluation
4
evaluation antiinflammatory
4
analgesic properties
4
properties 1-[quinolyl4]-123-triazoles
4
1-[quinolyl4]-123-triazoles synthesized
4
synthesized 13-dipolar
4
13-dipolar cycloaddition
4
cycloaddition 4-azidoquinolines
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!