[Nuclear proteins of human leukocytes in health and in chronic leukemias].

The levels and fractional composition of nuclear proteins of human leukocytes (histones, total non-histone proteins and HMG-proteins) have been studied in healthy subjects and cases of leukemia. It has been shown that the levels of histones and total non-histone proteins in normal myeloid cells are, on the average, 1.5 times those in lymphoid cells. Leukemia has been shown to involve elevated concentrations of high-molecular components in the histone and HMG-protein fraction of white blood cells as well as a slight decrease in both high- and low-molecular components in the fraction of total non-histone proteins. This points to disturbances in the epigenomic regulation of the genome involved in leukemia.