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Numerical Investigation of a Microfluidic Biosensor Based on I-Shaped Micropillar Array Electrodes.
Sensors (Basel)
December 2024
Department of Electrical and Computer Engineering, Bucknell University, Lewisburg, PA 17837, USA.
Micropillar array electrodes offer several advantages, such as enhanced mass transport, lower detection limits, and the potential for miniaturization, making them instrumental in the design and fabrication of electrochemical biosensors. The performance of these biosensors is influenced by electrode geometry, including parameters like shape and height, which affect surface area and overall sensitivity. In this study, we designed a microfluidic electrochemical biosensor featuring micropillar array electrodes, modeled in COMSOL Multiphysics.
View Article and Find Full Text PDFEmerging Sensing Technologies for Liquid Biopsy Applications: Steps Closer to Personalized Medicine.
Sensors (Basel)
December 2024
Department of Chemistry, University of Patras, GR26504 Patras, Greece.
Liquid biopsy is an efficient diagnostic/prognostic tool for tumor-derived component detection in peripheral circulation and other body fluids. The rapid assessment of liquid biopsy techniques facilitates early cancer diagnosis and prognosis. Early and precise detection of tumor biomarkers provides crucial information about the tumor that guides clinicians towards effective personalized medicine.
View Article and Find Full Text PDFA Signal-On Microelectrode Electrochemical Aptamer Sensor Based on AuNPs-MXene for Alpha-Fetoprotein Determination.
Sensors (Basel)
December 2024
Innovation Platform of Micro/Nano Technology for Biosensing, ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 311200, China.
As a crucial biomarker for the early warning and prognosis of liver cancer diseases, elevated levels of alpha-fetoprotein (AFP) are associated with hepatocellular carcinoma and germ cell tumors. Herein, we present a novel signal-on electrochemical aptamer sensor, utilizing AuNPs-MXene composite materials, for sensitive AFP quantitation. The AuNPs-MXene composite was synthesized through a simple one-step method and modified on portable microelectrodes.
View Article and Find Full Text PDFEffects of Phenoxazine Chromophore on Optical, Electrochemical and Electrochromic Behaviors of Carbazole-Thiophene Derivatives.
Polymers (Basel)
December 2024
Henan Key Laboratory of Rare Earth Functional Materials, The Key Laboratory of Rare Earth Functional Materials and Applications, Zhoukou Normal University, Zhoukou 466001, China.
Phenoxazine, as an organic-small-molecule chromophore, has attracted much attention for its potential electrochromic applications recently. To develop appealing materials, phenoxazine chromophores were introduced at the N-position of carbazole-thiophene pigment, yielding two novel monomers (DTCP and DDCP), whose chemical structures were characterized by NMR, HRMS and FTIR. The results of the optical property study indicate that little influence could be observed in the presence of the phenoxazine chromophore.
View Article and Find Full Text PDFOptimizing Heavy Metal Uptake in Through Electrokinetic Treatment: A Comprehensive Study on Phytoremediation from Mine Tailings.
Toxics
November 2024
Sede Vallenar, Universidad de Atacama, Av. Costanera #105, Vallenar 1612178, Chile.
Copper mining drives economic growth, with the global demand expected to reach 120 million metric tons annually by 2050. However, mining produces tailings containing heavy metals (HMs), which poses environmental risks. This study investigated the efficacy of phytoremediation (Phy) combined with electrokinetic treatment (EKT) to increase metal uptake in grown in tailings from the Metropolitan Region of Chile.
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