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A Subtle Adversary: Mycobacterium avium-intracellulare Infection of the Surgical Site Years After Bilateral Lung Transplantation.
Cureus
October 2024
Department of Medicine, Division of Pulmonology, University of Kentucky, Lexington, USA.
complex is a nontuberculous that has been associated with a wide range of infections, including the skin and soft tissues, central nervous system, and pulmonary system. We discuss the case of a 66-year-old male with a history of coal worker's pneumoconiosis who had undergone a bilateral lung transplant eight years prior and presented with drainage from his right chest incision site. He underwent operative exploration and drainage of the wound.
View Article and Find Full Text PDFDiagnosis, prevention and risk-management of drug-induced liver injury due to medications used to treat mycobacterium tuberculosis.
Expert Opin Drug Saf
September 2024
Department of Medicine, Division of Infectious Diseases, Washington, DC, USA.
Introduction: Many of the first line medications for the treatment of active and latent M. tuberculosis are hepatoxic and cause a spectrum of anti-tuberculosis drug induced liver injury (ATLI), including acute liver failure (ALF). Despite advances in recognition of and prevention of ATLI, isoniazid remains one of the leading causes of DILI as well as drug-induced ALF.
View Article and Find Full Text PDFEfficacy of rifapentine and other rifamycins against .
Microbiol Spectr
July 2024
Rickettsial Zoonoses Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Unlabelled: Since 1999, doxycycline and hydroxychloroquine have been the recommended treatment for chronic Q fever, a life-threatening disease caused by the bacterial pathogen, . Despite the duration of its use, the treatment is not ideal due to the lengthy treatment time, high mortality rate, resistant strains, and the potential for contraindicated usage. A literature search was conducted to identify studies that screened large panels of drugs against to identify novel targets with potential efficacy against .
View Article and Find Full Text PDFPrevalence of antibiotic resistance in clinical isolates of : a systematic review and meta-analysis.
Expert Rev Anti Infect Ther
August 2024
Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- * A thorough review of research articles up to February 2023 identified 17 studies that evaluated antibiotic resistance in specific NTM species using data from multiple databases.
- * Results showed varying resistance rates to antibiotics, with significant findings such as 0% resistance to clarithromycin, amikacin, and linezolid, but notably high resistance of 96% to doxycycline and 49% to SXT, emphasizing the importance of careful antibiotic management and further investigation into resistance mechanisms.
Using Dynamic Oral Dosing of Rifapentine and Rifabutin to Simulate Exposure Profiles of Long-Acting Formulations in a Mouse Model of Tuberculosis Preventive Therapy.
Antimicrob Agents Chemother
July 2023
Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Administration of tuberculosis preventive therapy (TPT) to individuals with latent tuberculosis infection is an important facet of global tuberculosis control. The use of long-acting injectable (LAI) drug formulations may simplify and shorten regimens for this indication. Rifapentine and rifabutin have antituberculosis activity and physiochemical properties suitable for LAI formulation, but there are limited data available for determining the target exposure profiles required for efficacy in TPT regimens.
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