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J Interferon Res
Division of Hematology and Oncology, Medizinische Hochschule Hannover, Germany.
Published: August 1994
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http://dx.doi.org/10.1089/jir.1994.14.177 | DOI Listing |
Clin Exp Immunol
March 2025
Antibody and Vaccine Group, School of Cancer Sciences, Centre for Cancer Immunology, University of Southampton Faculty of Medicine, Southampton, Hampshire, SO16 6YD, UK.
Fc receptors (FcR) play a key role in coordinating responses from both the innate and adaptive immune system. The inhibitory Fc gamma receptor (FcγRIIB/CD32B; referred to as FcγRII in mice) restrains the immune response, specifically through regulating immunoglobulin G (IgG) effector functions. FcγRII-deficient mice demonstrate elevated incidence and severity of autoimmunity and increased responses to immunization and infections.
View Article and Find Full Text PDFEur J Med Res
March 2025
Department of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, 138 Sheng Li Road, Tainan, Taiwan.
Objective: Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors are a standard therapy for patients who respond poorly to or cannot tolerate statins. However, identifying responders to PCSK9 inhibitors remains unclear. This study investigates the characteristics of patients who achieve target LDL-C reduction (< 70 mg/dl) after PCSK9 inhibitor therapy.
View Article and Find Full Text PDFCommun Biol
March 2025
Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
During human immunodeficiency virus (HIV-1) entry, the metastable pretriggered envelope glycoprotein (Env) trimer ((gp120/gp41)) opens asymmetrically. We present cryo-EM structures of cleaved asymmetric Env trimers in amphipol-lipid nanodiscs. The gp41 membrane-proximal external region (MPER) could be traced in Env protomers that remained close to the nanodisc despite Env tilting.
View Article and Find Full Text PDFAnn Clin Lab Sci
January 2025
Department of Pediatrics, Division of Infectious Diseases, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA.
Objective: is a gram-negative intracellular bacterium that causes respiratory infections and may contribute to inflammatory responses in asthma. Cell-mediated immune responses are important for protective immunity against ; however, these responses may be impaired in asthma. Interleukin (IL)-10 is a cytokine that modulates innate and adaptive immunity.
View Article and Find Full Text PDFAllergol Immunopathol (Madr)
March 2025
Register of Severe Asthma of the Region of Murcia (RE-ASGRAMUR) Group (names listed in the Appendix).
Background: Tezepelumab is a human monoclonal antibody which inhibits the cytokine thymic stromal lymphopoietin and is effective in different asthma endotypes.
Methods: This is a prospective, multicenter study of the Register of Severe Asthma of the Region of Murcia (RE-ASGRAMUR) Group performed under routine clinical practice conditions.
Results: We present a series of 57 patients who completed at least 6 months of treatment with tezepelumab.
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