The implantation of embryonic testis grafts into female chick embryos induces the regression of their müllerian ducts (MDs) in a certain number of cases. The treatment of either the grafts or the grafted females with testosterone propionate (TP) results in a significant increase in the number of MD regressions observed. Our data are interpretable in terms of a direct activation by TP of the anti-müllerian activity of the embryonic testis. We discuss a possible mechanism accounting for the synergistic action of testosterone and anti-müllerian hormone.
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