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A thermal protective urethral heater applied to modulate the prostate cryoablation area.
Cryo Letters
June 2018
Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and MolecularEngineering, East China University of Science and Technology, Shanghai, China.
Background: Urethral warmer and cryoheater are invented and applied in cryoablation to overcome urethral cryoinjury, but these devices cannot be fixed and precisely control the released heat which excessively reduces the effective ablation area. Current warmers enlarge the operation difficulty and decrease the precision in temperature control.
Objective: A reformed catheter termed urethral heater aims to protect the urethra and simultaneously control the released heat so as to meet the aid of doctors' convenient operation in effective therapy, device fixation and precise heat controllability.
An investigation of the effects from a urethral warming system on temperature distributions during cryoablation treatment of the prostate: a phantom study.
Cryobiology
August 2014
Department of Urology, Mayo Clinic, Rochester, MN 55905, United States. Electronic address:
Introduction of urethral warmers to aid cryosurgery in the prostate has significantly reduced the incidence of urethral sloughing; however, the incidence rate still remains as high as 15%. Furthermore, urethral warmers have been associated with an increase of cancer recurrence rates. Here, we report results from our phantom-based investigation to determine the impact of a urethral warmer on temperature distributions around cryoneedles during cryosurgery.
View Article and Find Full Text PDFHow I do it: prostate cryoablation (PCry).
Can J Urol
April 2014
Denver Health Medical Center/University of Colorado Cancer Center, Denver, Colorado, USA.
Prostate cryoablation (PCry) is a well-established minimally invasive therapy for the treatment of prostate cancer. Unfortunately, PCry still carries the stigma of a high rate recto-urethral fistula procedure but with the advent of argon/helium gas technology, urethral warmer and high quality transrectal ultrasound imaging, complications decreased and efficacy increased. The Denver Health Medical Center's technique in prostate cryoablation is described as follows.
View Article and Find Full Text PDFMR imaging-guided focal cryoablation in patients with recurrent prostate cancer.
Radiology
August 2013
Department of Radiology, Radboud University Nijmegen Medical Centre, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands.
Purpose: To assess the feasibility of magnetic resonance (MR) imaging-guided focal cryoablation in patients with locally recurrent prostate cancer after radiation therapy.
Materials And Methods: This was a prospective study, and informed consent was obtained from all patients. Ten consecutive patients with histopathologically proved recurrent prostate cancer after radiation therapy, without evidence of distant metastases, were treated while under general anesthesia in a 1.
Laser-assisted cryosurgery in ex vivo mice hepatic tissue: viability assays using green fluorescent protein.
Ann Biomed Eng
February 2011
Department of Mechanical Engineering, University of California, Riverside, CA 92521, USA.
An experimental investigation is carried out to develop a novel approach to cryosurgery, where laser heating counteracts tissue freezing to better confine damage to the targeted cancerous tissue within a lethal low-temperature isothermal boundary-an approach we refer to as laser-assisted cryosurgery (LAC). The advantage of this procedure relative to conventional cryosurgery assisted with urethral warmers or cryoheaters is that laser heating provides volumetric rather than superficial heating, which leads to deeper penetration, more homogeneous tissue protection and better demarcation of the destructive freezing effect to a well-defined targeted volume. Tissue viability assays are performed using green fluorescence protein (GFP) as a viability marker and correlated with temperature history after performing LAC procedures on ex vivo mice hepatic tissue.
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