A concentration of 250 mg m-3 lincomycin was administered by aerosol to 40 chickens, weighing between 1900 and 2200 g. The birds were killed in groups of five at different intervals after dosing, and the trachea, lungs and blood serum were examined for antibiotic content by bioassay. The antibiotic was present at high levels in the trachea for one to 24 hours, and significant levels were present in the lungs and serum. Respiratory macrophages were obtained from the lungs and air sacs of the chickens by lavaging through the surgically prepared trachea with a paediatric urinary catheter. The macrophages were identified by morphology as round or slightly amorphous, refractile, frequently grannular cells; they phagocytosed Staphylococcus aureus 6538.
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http://dx.doi.org/10.1016/0034-5288(94)90065-5 | DOI Listing |
J Postgrad Med
October 2024
Department of Microbiology, Government Medical College, Nagpur, Maharashtra, India.
Introduction: The World Health Organization added methicillin-resistant S aureus (MRSA) to the list of "priority pathogens," given its capacity to cause life-threatening infections. Clindamycin is a preferred treatment for non-complicated S aureus-induced skin and soft tissue infections. Its good tissue penetration and oral absorption make it suitable for outpatient therapy.
View Article and Find Full Text PDFEur J Drug Metab Pharmacokinet
March 2024
Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000, Novi Sad, Serbia.
Background And Objective: Topical clindamycin formulations are widely used in clinical practice, but poor bioavailability and restricted skin penetration considerably limit their therapeutic efficacy. Penetration enhancement represents a promising and rational strategy to overcome the drawbacks of conventional topical pharmaceutical formulations. We aim to assess the influence of cholic acid (CA) and deoxycholic acid (DCA) on the permeability of clindamycin hydrochloride by performing the in vitro skin parallel artificial membrane permeability assay (skin-PAMPA) at two relevant pH values (5.
View Article and Find Full Text PDFPoult Sci
January 2024
College of Veterinary Medicine (BK21 FOUR Program), Chungnam National University, Daejeon 34131, Republic of Korea. Electronic address:
Lincomycin (LCM) is an antibiotic used to treat severe bacterial infections in livestock and companion animals. In this study, we aimed to investigate the oral bioavailability of LCM with PK data after IV and PO administration and to compare differences in drug residue patterns in eggs. To ensure food safety, an additional study on egg residue was conducted using 3 different commercial LCM drugs.
View Article and Find Full Text PDFInt J Pharm
November 2023
Pharmaceutical Technology Department, National Research Centre, Dokki, Cairo 12622, Egypt; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ahram Canadian University, 6(th) of October City, Cairo, Egypt. Electronic address:
This study aims to develop a pharmaceutical formulation that combines the potent antibacterial effect of lincomycin and lauric acid against Cutibacterium acnes (C. acnes), a bacterium implicated in acne. The selection of lauric acid was based on an in silico study, which suggested that its interaction with specific protein targets of C.
View Article and Find Full Text PDFJ Antimicrob Chemother
August 2023
Department of Gastroenterology and Hepatology, Radboud university medical center, Nijmegen, the Netherlands.
Background: The use of oral antimicrobial agents in patients with short bowel syndrome (SBS) is challenging due to the changes in gastrointestinal anatomy that may result in diminished absorption and altered drug bioavailability. Prospective studies evaluating bioavailability of antimicrobial agents after oral administration in SBS patients are lacking.
Objectives: To determine the bioavailability of orally administered antimicrobial agents commonly used for treatment in SBS patients to guide clinical decision making when faced with infections.
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