AI Article Synopsis
- In adult mammals, the main type of cell division is called renewal growth, where stem cells divide asymmetrically, producing one stem cell and one differentiated cell.
- Disruptions in this renewal process can lead to cancer development.
- The p53 antioncogene plays a crucial role in regulating this process by promoting an asymmetric growth pattern in rapidly dividing cells, highlighting its importance in preventing cancer.
Article Abstract
The predominant type of cell division in adult mammals is renewal growth. Renewing stem cells in somatic tissues undergo continuous asymmetric divisions. One new daughter cell retains the division potential of the original stem cell, while the other differentiates into a functional constituent of the tissue. Disruptions of this process lead to the development of human cancers. We show that through a guanine nucleotide-dependent mechanism, the p53 antioncogene can induce exponentially dividing cells to switch to an asymmetric stem cell growth pattern. This finding suggests that the observed high frequency of p53 mutations in human cancers reflects a critical function in the regulation of somatic renewal growth.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC42832 | PMC |
| http://dx.doi.org/10.1073/pnas.92.1.136 | DOI Listing |
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