With advances in polymer chemistry, polymeric implants are becoming an increasingly attractive alternative to autogenous bone. Although polymeric implants were traditionally used to bridge bony defects and modify the overlying soft tissue envelope, new resorbable polymers may allow bony replacement and may be used as alternatives to metals in rigid fixation. This article contains an overview of polymeric implants from acrylics to modern resorbable polymers.
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Zhongguo Gu Shang
January 2025
Department of Orthopaedics, Sir Run Run Shaw Hospital, Hangzhou 310016, Zhejiang, China.
Objective: To observe the clinical outcomes of anterior approach for the revision surgery following unsuccessful bone cement augmentation in osteoporotic vertebral compression fractures.
Methods: A total of 10 patients who experienced unsuccessful bone cement augmentation underwent anterior revision surgery between January 2020 and December 2021. There were 2 males and 8 females.
BMJ Case Rep
January 2025
Pneumology, Centre Hospitalier du Valais Romand, Sion, Switzerland.
A woman in her mid-70s presented with worsening dyspnoea, cough and fatigue initially treated for pneumonia. Despite antibiotics, her condition deteriorated, prompting further investigation. Medical history included previous breast implants, the latter of which had ruptured years earlier and was subsequently removed prior to the current presentation.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
School of Food Science, Guangdong Pharmaceutical University, Zhongshan 528458, People's Republic of China; GDPU-HKU Zhongshan Biomedical Innovation Platform, Zhongshan 528437, People's Republic of China. Electronic address:
Guar gum based bacterial cellulose (GG-BC) was generated from the soy sauce residue hydrolysate by in-situ fermentation, and its structure and performance were learned systematically. The GG concentration of 0.2 % was most suitable for GG-BC production with the yield of 1.
View Article and Find Full Text PDFInt J Nanomedicine
January 2025
Department of Orthopedics, the First Hospital of Lanzhou University, Lanzhou, People's Republic of China.
Background: Given the risks associated with autologous bone transplantation and the limitations of allogeneic bone transplantation, scaffolds in bone tissue engineering that incorporate bioactive peptides are highly recommended. Teriparatide (TPTD) plays a significant role in bone defect repair, although achieving controlled release of TPTD within a bone tissue engineering scaffold remains challenging. This work reports a new approach for treatment of teriparatide using a water-in-oil-in-water (w/o/w) microspheres be equipped on gelatin (GEL)/Poly lactic-glycolic acid (PLGA)/attapulgite (ATP) scaffold.
View Article and Find Full Text PDFJ Mater Chem B
January 2025
Harris Orthopaedic Laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Total joint replacement is a successful procedure for restoring the patient's musculoskeletal mobility and quality of life, but it carries the risk of severe peri-prosthetic joint infections (PJI) and is accompanied by post-operative pain. Cocktails of multiple drugs are often used for prevention/treatment of PJI and for addressing pain. Local drug delivery systems are promising for improving the outcome of the treatment and decreasing the side effects of systemic drugs.
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