AI Article Synopsis
- Hepatitis viruses may increase liver cancer risk through two main mechanisms:
- 1. They kill liver cells and stimulate cell division, which raises the chances of mutations that can lead to cancer.
- 2. They cause chromosomal instability by producing proteins that promote genetic recombination during chronic hepatitis infection.
Article Abstract
We propose that hepatitis virus can cause an increase in the incidence of liver cancer by a combination of two mechanisms: (1) cell killing and stimulation of mitosis leading to an accumulation of events necessary for transformation, and (2) an increase in chromosomal instability mediated by induced recombinogenic protein(s) during chronic hepatitis.
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| http://dx.doi.org/10.1159/000150368 | DOI Listing |
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