AI Article Synopsis
- The study tested metaproterenol, a beta-2 adrenergic agonist, on muscle size and strength in men with muscle atrophy due to spinal cord injury.
- Ten male participants were split into two groups, receiving either metaproterenol or a placebo for 4 weeks, with muscle strength measured through an advanced force transducer.
- Results showed significant improvements in both muscle strength and size in those taking metaproterenol compared to the placebo group, suggesting potential benefits for individuals with muscle atrophy from spinal cord injuries.
Article Abstract
The administration of beta-2 adrenergic agonists in experimental animals result in an increased strength of skeletal muscle. In this study, we evaluated whether a beta-2 adrenergic agonist, metaproterenol, had an effect on muscle size and strength in a group of patients with muscular atrophy following spinal cord injury. Ten male subjects were randomly divided into 2 groups and agreed to participate in a prospective, double-blind, placebo-controlled, and crossover study. Metaproterenol (80 mg/day), or placebo, was administered orally for a period of 4 weeks. Muscle strength was measured by a force transducer interfaced with a microcomputer. Muscle size was calculated and expressed as a cross-sectional area of upper arm and forearm using a formula. Metaproterenol induced a significant increase of muscle strength in both groups of subjects, compared with placebo (p < .001). Similarly, there was an increase in a muscle size in the forearm following the administration of metaproterenol. Our data indicate that beta-2 adrenergic agonists may improve both muscle strength and size in patients with muscular atrophy following spinal cord paralysis.
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| http://dx.doi.org/10.1016/s0003-9993(95)80043-3 | DOI Listing |
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