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Identify biological Alzheimer's disease using a novel nucleic acid-linked protein immunoassay.
Brain Commun
January 2025
Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Montreal, QC, Canada H4H 1R2.
Blood-based biomarkers have been revolutionizing the detection, diagnosis and screening of Alzheimer's disease. Specifically, phosphorylated-tau variants (p-tau, p-tau and p-tau) are promising biomarkers for identifying Alzheimer's disease pathology. Antibody-based assays such as single molecule arrays immunoassays are powerful tools to investigate pathological changes indicated by blood-based biomarkers and have been studied extensively in the Alzheimer's disease research field.
View Article and Find Full Text PDFTranslocating individuals from multiple source populations is one way to bolster genetic variation and avoid inbreeding in newly established populations. However, mixing isolated populations, especially from islands, can potentially lead to outbreeding depression and/or assortative mating, which may limit interbreeding between source populations. Here, we investigated genetic consequences of mixing individuals from two island populations of the dibbler () in an island translocation.
View Article and Find Full Text PDFDesign strategies for organelle-selective fluorescent probes: where to start?
RSC Adv
January 2025
Genome Institute of Singapore (GIS), Agency for Science, Technological, and Research (A*STAR) 60 Biopolis Street, Genome Singapore 138672.
Monitoring physiological changes within cells is crucial for understanding their biological aspects and pathological activities. Fluorescent probes serve as powerful tools for this purpose, offering advantageous characteristics over genetically encoded probes. While numerous organelle-selective probes have been developed in the past decades, several challenges persist.
View Article and Find Full Text PDFAn AI recognition method for children's clinical operative pain by skin potential (SP) signal.
Heliyon
January 2025
College of Information Science and Electronic Engineering, Zhejiang University, Hangzhou, 310027, China.
Objective And Rationale: Children's clinical pain phenotypes are complex, and there is a lack of objective biological diagnostic markers and cognitive patterns. Detecting physiological signals through wearable devices simplifies disease diagnosis and holds the potential for remote medical applications.
Method And Results: This research established a pain recognition model based on AI skin potential (SP) signal analysis.
Dynamic in vivo monitoring of granum structural changes of Ctenanthe setosa (Roscoe) Eichler during drought stress and subsequent recovery.
Physiol Plant
January 2025
Department of Plant Anatomy, Institute of Biology, Faculty of Science, ELTE Eötvös Loránd University, Budapest, Hungary.
Investigating the effects of drought stress and subsequent recovery on the structure and function of chloroplasts is essential to understanding how plants adapt to environmental stressors. We investigated Ctenanthe setosa (Roscoe) Eichler, an ornamental plant that can tolerate prolonged drought periods (40 and 49 days of water withdrawal). Conventional biochemical, biophysical, physiological and (ultra)structural methods combined for the first time in a higher plant with in vivo small-angle neutron scattering (SANS) were used to characterize the alterations induced by drought stress and subsequent recovery.
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