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Naltrexone promotes mechanical allodynia in humans and rats.
Neurosci Lett
August 2022
Université Clermont Auvergne, TGI, CNRS, Clermont Auvergne INP, Institut Pascal, 63000 Clermont-Ferrand, France. Electronic address:
Mechanical allodynia has been studied in chronic naltrexone-treated people (N.T.P.
View Article and Find Full Text PDFSuccessive treatment with naltrexone induces epithelial-mesenchymal transition and facilitates the malignant biological behaviors of bladder cancer cells.
Acta Biochim Biophys Sin (Shanghai)
February 2021
Department of Anesthesiology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 200127, China.
Naltrexone is widely used for alleviating opioid-related side effects in cancer patients. However, the effects of naltrexone on cancer progression are controversial in the literature. The present study was carried out to investigate the effects of successive treatment with clinically relevant doses of naltrexone on the malignant biological behaviors of bladder cancer cells.
View Article and Find Full Text PDFOpioid receptors inhibit the spinal AMPA receptor Ca permeability that mediates latent pain sensitization.
Exp Neurol
April 2019
Department of Anesthesiology, Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, 200 Lothrop St. Pittsburgh, PA 15213, USA; Department of Physiology, University of Kentucky School of Medicine, 800 Rose, St. Lexington, KY 40536-0298, USA. Electronic address:
Acute inflammation induces sensitization of nociceptive neurons and triggers the accumulation of calcium permeable (CP) α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) in the dorsal horn of the spinal cord. This coincides with behavioral signs of acute inflammatory pain, but whether CP-AMPARs contribute to chronic pain remains unclear. To evaluate this question, we first constructed current-voltage (IV) curves of C-fiber stimulus-evoked, AMPAR-mediated EPSCs in lamina II to test for inward rectification, a key characteristic of CP-AMPARs.
View Article and Find Full Text PDFMu-opioid receptor inhibition decreases voluntary wheel running in a dopamine-dependent manner in rats bred for high voluntary running.
Neuroscience
December 2016
Department of Biomedical Sciences, University of Missouri, Columbia, MO, United States; Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, United States; Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, United States; Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, United States. Electronic address:
The mesolimbic dopamine and opioid systems are postulated to influence the central control of physical activity motivation. We utilized selectively bred rats for high (HVR) or low (LVR) voluntary running behavior to examine (1) inherent differences in mu-opioid receptor (Oprm1) expression and function in the nucleus accumbens (NAc), (2) if dopamine-related mRNAs, wheel-running, and food intake are differently influenced by intraperitoneal (i.p.
View Article and Find Full Text PDFOpioid-receptor antagonism increases pain and decreases pleasure in obese and non-obese individuals.
Psychopharmacology (Berl)
December 2016
Faculty of Medicine, McGill University, Strathcona Anatomy and Dentistry Building, Bldg Rm M/19, 3640 Rue University, Montreal, QC, H3A 0C7, Canada.
Rationale: Endogenous opioids inhibit nociceptive processing and promote the experience of pleasure. It has been proposed that pain and pleasure lie at opposite ends of an affective spectrum, but the relationship between pain and pleasure and the role of opioids in mediating this relationship has not been tested.
Objectives: Here, we used obese individuals as a model of a dysfunctional opioid system to assess the role of the endogenous opioid peptide, beta-endorphin, on pain and pleasure sensitivity.
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