Effect of treatment with contraceptive steroids on the sexual behaviour of rats pretreated with benzpyrene or allylestrenol in fetal or neonatal age.

Treatments with contraceptive steroids significantly reduced the receptivity of adult female rats. This effect was not observed in ovariectomized females treated with high doses of estrogen and gestagen hormones prior to the investigation. The receptivity was also significantly reduced in rats treated with steroids (allylestrenol or benzpyrene) in their fetal or neonatal age, as it was demonstrated in previous experiments. The contraceptive treatment of the above described, pretreated adults resulted in improved function of receptivity, but it had no difference compared to the group which was only treated with anticoncipient. This means that neonatal treatment with allylestrenol or benzpyrene does not influence the effects of contraceptive steroids on the sexual behaviour (receptivity). The two effects are not additive.