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Effect of catalase on CPC production during fermentation of Acremonium chrysogenum.
Bioresour Bioprocess
January 2025
Qingdao Innovation Institute of East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China.
Cephalosporin C (CPC) is a critical raw material for cephalosporin antibiotics produced by Acremonium chrysogenum. During fermentation, the oxygen supply is a crucial factor limiting the efficient biosynthesis of CPC. This study demonstrated that the addition of exogenous surfactants significantly increased the dissolved oxygen (DO) level, extracellular catalase content, and final CPC titer.
View Article and Find Full Text PDFChallenges with effective removal of surfactants from monoclonal antibody formulations.
Int J Pharm
December 2024
Department of Pharmaceutical Sciences & Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA 52242, the United States of America. Electronic address:
Buffer exchange is a critical step in biologics development, playing a pivotal role in removing contaminants, adjusting sample conditions, and facilitating compatibility studies. The efficiency of centrifugal concentrators for polysorbate removal was compared to a two-step approach involving a surfactant removal column followed by buffer exchange. Trastuzumab-pkrb from Herzuma® was used.
View Article and Find Full Text PDFInterfacial tension reduction using nitrogen graphene quantum dots with various precursors, molar ratios, and synthesis durations for enhanced oil recovery.
Sci Rep
December 2024
Department of Petroleum and Geoenergy Engineering, Amirkabir University of Technology, Tehran, Iran.
Nanofluids have the capacity to reduce interfacial tension (IFT) of crude oil and water for enhanced oil recovery (EOR) operations, but traditional nanoparticles are limited in tight reservoirs due to their inappropriate size for micro-nano pores and their tendency to aggregate. In this paper, Graphene Quantum Dots (GQDs) with simple and favorable properties are developed, and their performance and mechanism for reducing IFT are evaluated. The paper also aims to explore the effects of GQD precursor type, synthesis duration, and molar percentages of precursors on reducing IFT.
View Article and Find Full Text PDFToward mechanistic understanding of wettability alteration in carbonate rocks in the presence of nanoparticles, gelatin biopolymer, and core-shell nanocomposite of FeO@gelatin.
Sci Rep
December 2024
Department of Petroleum Engineering, Shahid Bahonar University of Kerman, Kerman, Iran.
Because a significant portion of oil remains in carbonate reservoirs, efficient techniques are essential to increase oil recovery from carbonate reservoirs. Wettability alteration is crucial for enhanced oil recovery (EOR) from oil-wet reservoirs. This study investigates the impact of different substances on the wettability of dolomite and calcite rocks.
View Article and Find Full Text PDFPulmonary Alveolar Proteinosis During Intensive Immunosuppressive Treatment for Acute Exacerbation of Interstitial Pneumonia: A Case Report and Literature Review.
Cureus
November 2024
Department of Respiratory Medicine and Clinical Immunology, Nippon Life Hospital, Osaka, JPN.
Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by the accumulation of surfactants in the alveoli. It has been suggested that immunosuppressants contribute to the development and exacerbation of PAP. Here, we report the case of a 73-year-old man who developed secondary PAP after intensive immunosuppressive treatment for acute exacerbation of interstitial pneumonia (IP).
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