AI Article Synopsis
- Blood CA125 levels were tested in 131 patients with different types of ovarian diseases, showing high sensitivity (96%), specificity (77%), and accuracy (73%) for diagnosis.
- In contrast, carcinoembryonic antigen (CEA) measurements in 101 patients revealed significantly lower values (sensitivity 60%, specificity 64%, accuracy 24%).
- The study concludes that CEA is unreliable as a standalone marker for diagnosing or monitoring ovarian cancer treatment due to its low levels in advanced stages and poor correlation with CA125.
Article Abstract
Blood CA125 carbohydrate antigen levels were measured in 131 patients with malignant, benign, and borderline ovarian diseases. Parallel measurements of carcinoembryonic antigen (CEA) were carried out in 101 of them. The diagnosis with CA125 measurements was found highly sensitive (96%), specific (77%), and accurate (73%). For CEA these values were, respectively, 60, 64, and 24%. Since CEA levels in the blood of ovarian cancer patients are not high even in stages III-IV condition, correlation between CEA and CA125 levels avsent, and the method of CEA measurements inaccurate, we think it unadvisable using CEA as a separate marker in diagnostic investigations, more so in monitoring the efficacy of treatment of patients with ovarian cancer.
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