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Melanocortin-4 receptor antagonist TCMCB07 alleviates chemotherapy-induced anorexia and weight loss in rats.
J Clin Invest
November 2024
Endevica Bio, Northbrook, Illinois, USA.
Cancer patients undergoing chemotherapy often experience anorexia and weight loss that substantially deteriorates overall health, reduces treatment tolerance and quality of life, and worsens oncologic outcomes. There are currently few effective therapeutic options to mitigate these side effects. The central melanocortin system, which plays a pivotal role in regulating appetite and energy homeostasis, presents a logical target for treating anorexia and weight loss.
View Article and Find Full Text PDFTransitions from child and adolescent to adult mental health services for eating disorders: an in-depth systematic review and development of a transition framework.
J Eat Disord
March 2024
Department of Psychiatry, University of Cambridge, Cambridge, England, UK.
Background: Eating disorders (EDs) peak in mid-to-late adolescence and often persist into adulthood. Given their early onset and chronicity, many patients transition from child and adolescent mental health services (CAMHS) to adult mental health services (AMHS) for ongoing, speciality ED care. This transition typically occurs at 18 years of age, when important biological, psychosocial, and vocational changes take place.
View Article and Find Full Text PDF[From diagnosis to symptoms].
Soins
December 2023
Cellule d'urgence médico-psychologique, Zone sud-ouest, 121 rue de la Bechade, CS 81285, 33076 Bordeaux cedex, France; Camea, 1 rue Saint-François-Xavier, 33170 Gradignan, France; Équipe AHeaD, Inserm U1219, Université de Bordeaux-Isped, 146 rue Léo-Saignat, 33076 Bordeaux cedex, France.
The diagnosis of anorexia nervosa is one of the easiest to make in that it is a positive diagnosis, not a differential diagnosis. It is defined by a few criteria which together become almost pathognomonic: excessive restriction of energy intake combined with an irrational fear of weight and an altered body image. Even if weight is at the heart of the medical team's concerns, it is important to question the pathology in its history, in order to put it in to context, and sometimes to understand the para-logic and its function in the patient's life history.
View Article and Find Full Text PDFImportance of different electronic medical record components for chronic disease identification in a Swiss primary care database: a cross-sectional study.
Swiss Med Wkly
October 2023
Institute of Primary Care, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Background: Primary care databases collect electronic medical records with routine data from primary care patients. The identification of chronic diseases in primary care databases often integrates information from various electronic medical record components (EMR-Cs) used by primary care providers. This study aimed to estimate the prevalence of selected chronic conditions using a large Swiss primary care database and to examine the importance of different EMR-Cs for case identification.
View Article and Find Full Text PDFCare pathways for longstanding eating disorders must offer paths to recovery, not managed decline.
BJPsych Bull
June 2024
Patient Representative, Faculty of Eating Disorders, Royal College of Psychiatrists, UK.
Eating disorders are historically underserved in healthcare, but are increasingly prevalent and recognised for their high costs regarding mortality, quality of life and the economy. Those with longstanding eating disorders are commonly labelled 'severe and enduring' (SEED), which has been challenged for its conceptual vagueness and potential to discourage patients. Attempts to define individuals from this cohort as having 'terminal' illness have also gained traction in recent years.
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