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http://dx.doi.org/10.1016/0735-1097(95)96216-l | DOI Listing |
Alzheimers Dement
December 2024
Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Background: The cognitive reserve (CR) theory seeks to explain the mismatch often reported between brain damage and its clinical expression. Unlike most previous studies that focused on individuals with memory deterioration before the diagnosis of Alzheimer's disease (AD), the present study examined the late stages of the disease. The study sought to confirm the hypothesis that patients with higher CR are diagnosed later and decline faster than those with lower CR because their brain pathology is more severe.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Iowa, Iowa City, IA, USA.
Background: The COVID-19 pandemic led to widespread social isolation and loneliness, especially among older adults aged 60 years and above. Loneliness is increasingly recognized as a significant public health concern given its association with adverse physical and mental health outcomes. However, less is known about the potential impact of loneliness on cognitive health and decline in older adults during the COVID-19 pandemic specifically.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Indiana University School of Medicine, Indianapolis, IN, USA.
Current joint practice guidelines (PG) on genetic counseling and testing for Alzheimer's disease (AD), published in 2011 by the National Society of Genetic Counselors (NSGC) and American College of Medical Genetics), recommend against clinical APOE genetic testing. These recommendations were largely followed, as seen in a survey of AD Research Centers in 2019 where only 7% of centers reported disclosure of APOE to research participants. However, because the risk of amyloid related imaging abnormalities (ARIA) associated with anti-amyloid therapy is increased for those with one or two copies of APOE e4, the FDA now endorses APOE testing for those considering this treatment.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Individuals with Mild Cognitive Impairment (MCI) and dementia are at greater risk for mental health conditions including depression and anxiety than those without cognitive impairments. Non-pharmacological interventions are considered first-line to address these problems, but access to psychotherapy services for these groups remains limited. Adapted evidence-based therapy approaches, including Cognitive Behavioral Therapy (CBT) and Acceptance and Commitment Therapy (ACT) are effective for treating comorbid mental health conditions in populations with cognitive impairments.
View Article and Find Full Text PDFObjective: Obesity is a disease with severe health impacts on individuals and economic impacts on society, yet healthcare practitioners (HCPs) and policy makers often fail to address it. This survey was conducted to examine current global obesity care and perceptions influencing care delivery among HCPs and healthcare decision makers (HC DMs).
Methods: A survey with a cross-sectional design was conducted among 1200 HCPs (primary care providers, endocrinologists, cardiologists, and nurses) and 414 HC DMs from eight countries across five continents.
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