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Patterns of spontaneous and induced genomic alterations in .
Appl Environ Microbiol
December 2024
Ocean College, Zhejiang University, Zhoushan, China.
Article Synopsis
- The study investigates genomic changes in a key yeast used in biotechnology under spontaneous and induced mutagenic conditions.
- Findings highlight a mutation rate of about 4 × 10 events per base pair per cell division, with specific patterns like C-to-T transitions as the most common spontaneous mutations.
- Exposure to mutagens like UV light and Zeocin significantly increases mutation rates, with Zeocin leading to unique substitution patterns and a higher frequency of insertions and deletions.
Treatment of giant fecalith colonic obstruction in a patient with Duchenne muscular dystrophy using endoscopic injection of hydrogen peroxide: a case report and literature review.
Front Med (Lausanne)
December 2024
Department of Hepatobiliary Surgery, First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang, China.
Introduction: Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder primarily affecting cardiac and skeletal muscles, with gastrointestinal obstruction being an infrequent complication.
Case Report: We present a 17-year-old boy with DMD (G-to-T transversion at c.4150 in the gene encoding dystrophin protein) who developed severe colonic obstruction due to fecal impaction.
Free Energy Landscape of Lesion Recognition by Human 8-Oxoguanine DNA N-Glycosylase 1: Mechanistic Insights into Detection and Processing of 8-Oxoguanine in DNA.
J Phys Chem B
December 2024
Department of Chemistry and Institute of Functional Materials, Pusan National University, Busan 46241, South Korea.
Human 8-oxoguanine DNA -glycosylase 1 (hOGG1) is an essential enzyme in DNA repair, responsible for recognizing and excising 8-oxoguanine (8OG), the lesion resulting from oxidative damage to guanine (G). By removing 8OG, hOGG1 prevents mutations like G-to-T transversions, maintains genomic stability, and reduces the risk of cancer and other diseases. Structural studies of hOGG1 bound to DNA have shown that lesion recognition occurs through base eversion from the DNA helix and hOGG1 finger residue insertion into the DNA helix.
View Article and Find Full Text PDFBackground: Diosgenin is an important steroidal precursor renowned for its diverse medicinal uses. It is predominantly sourced from Dioscorea species, particularly Dioscorea zingiberensis. Dioscorea zingiberensis has an ability to accumulate 2-16% diosgenin in its rhizomes.
View Article and Find Full Text PDFCandidate Gene Identification and Transcriptome Analysis of Tomato - and Functional Marker Development for - and Its Alleles, -, -, and -.
Int J Mol Sci
March 2024
State Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Male sterility is a valuable trait for hybrid seed production in tomato (). The mutants - (-) and - of tomato exhibit twisted stamens, exposed stigmas, and complete male sterility, thus holding potential for application in hybrid seed production. In this study, the - and - loci were fine-mapped to 53.
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