Author provides a description of septic shock in a parturient. He analyses the clinical cause and proposes a therapeutic behaviour during labour and puerperium.
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Research trends and hotspots on septic shock: a bibliometric study and visualization analysis.
Front Med (Lausanne)
November 2024
Department of Emergency Medicine, General Hospital of Northern Theater Command, Shenyang, Liaoning, China.
Background: Septic shock, the most severe stage of sepsis, causes potential circulatory failure and abnormal cell metabolism which are severe enough to affect prognosis, increase mortality, and impose significant burdens on the medical system. Despite a growing number of studies exploring the pathophysiology, epidemiology, and risk factors, research trends and hotspots in septic shock remain lacking. This study aims to create a visual knowledge map, identify research hotspots, and predict prospective trends based on bibliometric analysis.
View Article and Find Full Text PDFInvestigation of the effects of melatonin on lung tissue through the NLRP3/TLR2/NEK7 pathway in an experimental endotoxemia model.
Cell Mol Biol (Noisy-le-grand)
November 2024
Yozgat Bozok University, Faculty of Medicine, Department of Anatomy, Yozgat, Turkey.
Article Synopsis
- - Sepsis is a serious condition characterized by inflammation and cell death, often leading to multiple organ failure, requiring quick medical attention; lipopolysaccharide (LPS) triggers inflammatory responses through specific receptors like TLR-2.
- - The study explores the role of melatonin (MEL) in reducing lung injury caused by LPS-induced septic shock in rats, highlighting its potential to lower the expressions of inflammatory markers NEK7, TLR2, and NLRP3.
- - Results showed that melatonin treatment reduced lung tissue damage, cell infiltration, and wall thickening, indicating that it may provide therapeutic benefits in managing sepsis-related acute lung injury.
Generation of a Mouse Model for the Study of Thyroid Hormones Regulatory Effect on the Immune System.
Methods Mol Biol
November 2024
Unidad de Oncogenómica, Servicio de Oncohematología, Fundación para la Investigación Biomédica del Hospital Universitario Niño Jesús, Madrid, Spain.
The generation of hypothyroid and hyperthyroid mouse models is one of the approaches used to investigate the complex interplay between thyroid hormones and the immune system. We present a detailed protocol describing how to induce endotoxic shock by lipopolysaccharide (LPS) administration, and how to investigate the role of immune populations, specifically macrophages, responding to endotoxemia.This book chapter provides the use of different molecular techniques, such as Western Blotting, Immunohistochemistry, q-PCR, Luciferase assays, or ChIP assays, with which researchers can gain valuable insights into the immune system's interaction with hormonal signaling pathways, for instance, examining the effect of thyroid hormones on signaling of STAT3, NF-κB, and ERK in response to LPS, and inflammatory mediators, such as interleukin-6 (IL-6) or tumor necrosis factor-alpha (TNFα) within these cells.
View Article and Find Full Text PDFMacrophages in the inflammatory response to endotoxic shock.
Immun Inflamm Dis
October 2024
Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China.
Article Synopsis
- Endotoxic shock, a major issue in ICUs, occurs when endotoxins trigger the innate immune system, particularly activating macrophages and leading to the production of inflammatory mediators that can cause severe health complications.
- The review emphasizes macrophages' dual roles, with M1 macrophages promoting inflammation and M2 macrophages supporting anti-inflammatory processes, which are crucial for restoring balance during endotoxic shock recovery.
- Understanding how macrophages regulate inflammation is key for developing targeted treatments for endotoxic shock, potentially leading to more effective therapeutic strategies.
Citrulline and ADI-PEG20 reduce inflammation in a juvenile porcine model of acute endotoxemia.
Front Immunol
August 2024
USDA-ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Background: Arginine is a conditionally essential amino acid that is depleted in critically ill or surgical patients. In pediatric and adult patients, sepsis results in an arginine-deficient state, and the depletion of plasma arginine is associated with greater mortality. However, direct supplementation of arginine can result in the excessive production of nitric oxide (NO), which can contribute to the hypotension and macrovascular hypo-reactivity observed in septic shock.
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