The effect of two methyluracil forms on the composition of lipids, the content of peroxidation products and the amount of lipid-soluble scavengers of free radicals was studied in rat liver and heart tissues. Both these forms caused an increase in content of total lipids in the animal liver tissue 2 hrs after injection, whereas beta-form increased 1.6-fold the content of cholesterol esters and 1.9-fold that of triglycerides in liver tissue, unlike the alpha-form which affected these parameters slightly. The effect of methyluracil polymorphic derivatives on lipid peroxidation (TBA-positive products) was not detected. The methyluracil beta-form, not affecting the total pool of hydrophobic antioxidants, was found to decrease the content of active scavengers of free radicals in rat liver and heart tissues, as well as beta-form decreased the content of vitamin E in these tissues. At the same time, the methyluracil alpha-form did not affect the composition of tissue hydrophobic antioxidants. These differences found in the effect of two methyluracil forms on lipid composition and lipid-soluble scavengers of free radicals may be responsible for biological nonequivalence of the drug polymorphic forms.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
TARGETING LUNG HEME IRON BY AEROSOL HEMOPEXIN ADMINSTRATION IN SICKLE CELL DISEASE PULMONARY HYPERTENSION.
Free Radic Biol Med
January 2025
University of Colorado, Anschutz Medical Campus School of Medicine| Translational research laboratory of Red Blood Cell Diseases and Hypoxia related illnesses| Cardiovascular Pulmonary Research (CVP) group, Pediatrics. Electronic address:
Lung tissue from human patients and murine models of sickle cell disease pulmonary hypertension (SCD-PH) show perivascular regions with excessive iron accumulation. The iron accumulation arises from chronic hemolysis and extravasation of hemoglobin (Hb) into the lung adventitial spaces, where it is linked to nitric oxide depletion, oxidative stress, inflammation, and tissue hypoxia, which collectively drive SCD-PH. Here, we tested the hypothesis that intrapulmonary delivery of hemopexin (Hpx) to the deep lung is effective at scavenging heme-iron and attenuating the progression of SCD-PH.
View Article and Find Full Text PDFPolymer-Free Electrospinning of β-Cyclodextrin-Oligolactide for Magnolol and Honokiol Pharmaceutical Formulations.
Pharmaceutics
January 2025
Faculty of Pharmacy, "Grigore. T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Magnolol (MG) and honokiol (HK) are bioactive compounds extracted from and trees with significant pharmacological properties, including antioxidant and antibacterial activity. However, their poor water solubility and low bioavailability limit the therapeutic potential. To address these limitations, this study aims to develop MG and HK formulations by co-electrospinning using custom-synthesized β-cyclodextrin-oligolactide (β-CDLA) derivatives.
View Article and Find Full Text PDFRed Currant ( L.) Fruit Waste Extract and Juice as Potential Spasmolytic Agents.
Plants (Basel)
January 2025
Department of Pharmacy, Faculty of Medicine, University of Niš, Dr. Zoran Djindjić Ave 81, 18000 Niš, Serbia.
Red currant ( L.) berries are rich in bioactive compounds and exhibit nutritive and protective features. This research examined the content of secondary metabolites of the red currant variety Redpoll lyophilized juice and waste extract and their antioxidative and spasmolytic effects.
View Article and Find Full Text PDFPhytochemical Composition and Antioxidant Activity of Manuka Honey and Ohia Lehua Honey.
Nutrients
January 2025
Orthodontics, Department of Conservative Odontology, Faculty of Dental Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Unlabelled: Honey is abundant in bioactive compounds, which demonstrate considerable therapeutic effects, particularly on oxidative stress and inflammation.
Objectives: This work sought to evaluate the antioxidant mechanisms of Manuka honey (MH) and Ohia Lehua honey (OLH), correlating them with phytochemical analyses in a rat model of experimentally induced inflammation.
Methods: The identification of polyphenolic compounds in the extracts was carried out using HPLC-ESI MS.
Unveiling the Phytochemical Diversity and Bioactivity of : A First Report Integrating Experimental and In Silico Approaches.
Pharmaceuticals (Basel)
January 2025
Department of Molecular Biology and Genetics, Faculty of Science, Kilis 7 Aralik University, 79000 Kilis, Türkiye.
: The genus is renowned for its diverse bioactive potential, yet the chemical composition and biological properties of remain inadequately explored. This study aimed to investigate the chemical profile, antioxidant capacity, and enzyme inhibitory activities of methanol extracts from various plant parts of . : Methanol extracts were obtained from leaves, stems, flowers, roots, and aerial portions of .
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!