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Introduction: Mu-opioid receptors (MORs) are G-coupled protein receptors with a high affinity for both endogenous and exogenous opioids. MORs are widely expressed in the central nervous system (CNS), peripheral organs, and the immune system. They mediate pain and reward and have been implicated in the pathophysiology of opioid, cocaine, and other substance use disorders.
View Article and Find Full Text PDFResearch Status and Direction of Chronic Obstructive Pulmonary Disease Complicated with Coronary Heart Disease: A Bibliometric Analysis from 2005 to 2024.
Int J Chron Obstruct Pulmon Dis
January 2025
Department of Radiology, The First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang, People's Republic of China.
Objective: There is increasing evidence that chronic obstructive pulmonary disease (COPD) is associated with coronary heart disease (CHD). In this study, we provide valuable insights in the field by examining the evolution of the relationship between COPD and CHD over the past 20 years.
Methods: A comprehensive computer search was conducted in the Web of Science (WOS) core dataset, covering literature on COPD combined with CHD from January 1, 2005, to August 20, 2024.
Visual analysis of research hotspots and trends in traditional Chinese medicine for depression in the 21st century: A bibliometric study based on citespace and VOSviewer.
Heliyon
January 2025
Department of Neurology, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, China.
Background And Objectives: Depression long been a key concern for scholars worldwide; however, the field of depression has not received sufficient attention in traditional Chinese medicine. It was not until the 21st century that research into depression gradually entered a period of rapid development, with an increasing number of academic studies published in major journals. However, one limitation of this field is that no scholars have yet summarised the development process and key research issues.
View Article and Find Full Text PDFFormation of cognitive maps in large-scale environments by sensorimotor integration.
Cogn Neurodyn
December 2025
School of Systems Science, Beijing Normal University, Beijing, 100875 China.
Hippocampus in the mammalian brain supports navigation by building a cognitive map of the environment. However, only a few studies have investigated cognitive maps in large-scale arenas. To reveal the computational mechanisms underlying the formation of cognitive maps in large-scale environments, we propose a neural network model of the entorhinal-hippocampal neural circuit that integrates both spatial and non-spatial information.
View Article and Find Full Text PDFVisual image reconstructed without semantics from human brain activity using linear image decoders and nonlinear noise suppression.
Cogn Neurodyn
December 2025
Image Processing Laboratory, University of Valencia, Valencia, Spain.
In recent years, substantial strides have been made in the field of visual image reconstruction, particularly in its capacity to generate high-quality visual representations from human brain activity while considering semantic information. This advancement not only enables the recreation of visual content but also provides valuable insights into the intricate processes occurring within high-order functional brain regions, contributing to a deeper understanding of brain function. However, considering fusion semantics in reconstructing visual images from brain activity involves semantic-to-image guide reconstruction and may ignore underlying neural computational mechanisms, which does not represent true reconstruction from brain activity.
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